Up-regulation of Serum MiR-130b-3p Level is Associated with Renal Damage in Early Lupus Nephritis

Scientific Reports
Wanpeng WangZhaohui Ni

Abstract

Systemic lupus erythematosus (SLE) is a common but severe autoimmune systemic inflammatory disease. Lupus nephritis (LN) is a serious complication of SLE,affecting up to 70% of SLE patients. Circulating microRNAs (miRNA) are emerging as biomarkers for pathological conditions and play significant roles in intercellular communication. In present research, serum samples from healthy control, early and late stage LN patients were used to analyze the expression profile of miRNAs by microarray. Subsequent study demonstrated that miR-130b-3p in serum of patients with early stage LN were significantly up-regulated when compared with healthy controls. In addition,we have also observed that the expression of a large amount of circulating microRNAs significantly decreased in patients with late stage LN. The further analysis found that the expression of serum miR-130b-3p was positively correlated with 24-hour proteinuria and renal chronicity index in patients with early stage LN.Transfection of renal tubular cellline(HK-2)with miR-130b-3p mimics can promote epithelial-mesenchymal transition (EMT). The opposite effects were observed when transfected with miR-130b-3p inhibitors. MiR-130b-3p negatively regulated ERBB2IP expression by directly...Continue Reading

References

Apr 1, 1977·Journal of the National Cancer Institute·T P KarpetskyC C Levy
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Jan J WeeningMichio Nagata
Sep 17, 2004·Nature·Gunter Meister, Thomas Tuschl
Oct 6, 2005·The Journal of Biological Chemistry·Christine McDonaldGabriel Nuñez
Aug 26, 2006·Nature Clinical Practice. Rheumatology·H Terence Cook, Marina Botto
Nov 15, 2006·Protein and Peptide Letters·Angelika Ress, Karin Moelling
Apr 26, 2007·Kidney International·T KanjanabuchA B Fogo
Jun 27, 2007·Molecular and Cellular Biology·Fangyan DaiXin-Hua Feng
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Sep 2, 2008·Arthritis Research & Therapy·Kaleb M PauleyEdward Kl Chan
Sep 6, 2008·PloS One·Shlomit GiladAyelet Chajut
Jul 7, 2010·Molecular Cell·Yujing ZhangChen-Yu Zhang
Jul 20, 2010·Biochimica Et Biophysica Acta·Jürgen Wittmann, Hans-Martin Jäck
Oct 19, 2010·The Journal of Rheumatology·Gang WangCheuk-Chun Szeto
Nov 30, 2010·Molecular Cancer·Jan C BraseHolger Sültmann
Feb 18, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stefano GattiGiovanni Camussi
Apr 5, 2011·Arthritis Research & Therapy·Vaishali R Moulton, George C Tsokos
May 4, 2011·Annals of Surgical Oncology·Linwah YipMarina N Nikiforova
May 14, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yiqin ZuoAgnes B Fogo
Jun 3, 2011·Journal of Autoimmunity·Efstathia K KapsogeorgouAthanasios G Tzioufas
Sep 6, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Calida S NealJonathan M Gleadle
Nov 15, 2011·Arthritis Research & Therapy·Thomas DörnerPeter E Lipsky
Nov 26, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Qiaodan ZhouGang Xu
Jul 5, 2012·Clinical & Developmental Immunology·Susan Yung, Tak Mao Chan
Feb 8, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shubham ShrivastavaRatna B Ray
Feb 13, 2013·Arthritis and Rheumatism·Anting Liu CarlsenNiels H H Heegaard
Mar 8, 2013·PloS One·François GlowackiChristelle Cauffiez
Jun 1, 2013·Journal of the American Society of Nephrology : JASN·Hua ZhouGabor G Illei
Sep 13, 2013·Neoplasia : an International Journal for Oncology Research·Tommaso ColangeloVittorio Colantuoni
Aug 27, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Can ZongTie-Mei Shi

❮ Previous
Next ❯

Citations

Mar 11, 2016·Clinical Reviews in Allergy & Immunology·Susan Yung, Tak Mao Chan
Jul 28, 2016·Experimental Cell Research·Lian-Ju LiDong-Qing Ye
Sep 18, 2016·Autoimmunity Reviews·Ji-Qing ChenMargit Zeher
May 5, 2017·International Reviews of Immunology·Bin WangJin-An Zhang
Jun 2, 2017·Current Opinion in Rheumatology·Xiong LeNan Shen
Jun 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Anna SoliniRosa Maria Bruno
Nov 15, 2019·EMBO Reports·Steven D GurienPing Wang
Jun 24, 2017·Clinical Kidney Journal·Alexander Hüttenhofer, Gert Mayer
Aug 9, 2017·Clinical Epigenetics·Zijun WangQianjin Lu
Aug 28, 2020·Journal of Cellular Physiology·Qiang GuoXia Li
Jun 26, 2020·Biomolecules·Mohammad TaheriSoudeh Ghafouri-Fard
Jul 15, 2017·Transplantation Direct·Roel BijkerkMarlies E J Reinders
Mar 20, 2020·International Journal of Molecular Sciences·Chary Lopez-PedreraCarlos Pérez-Sánchez
Aug 14, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lei ZhangQingguang Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
PCR
transfection

Software Mentioned

RNAhybrid
PITA
miRWalk
miRDB
GraphPad
DIANAmT
RNA22
miRanda
GraphPad Prism
Pro Analyzer

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.