Up-regulation of uncoupling protein 3 (UCP3) mRNA by exercise training and down-regulation of UCP3 by denervation in skeletal muscles

Biochemical and Biophysical Research Communications
N Tsuboyama-KasaokaO Ezaki

Abstract

In skeletal muscles, increased utilization of lipids and carbohydrates accompanied with increased energy expenditure has been observed during and after exercise. UCP3, mitochondrial uncoupling protein, is expressed in skeletal muscles. We investigated UCP3 mRNA levels in exercise training mice which increased energy expenditure and in sciatic nerve-denervated mice which decreased energy expenditure. Mice exercised by 2 wk swimming had 14- to 18-fold increases of UCP3 mRNA in skeletal muscles 3 h after the last swimming, but no increases of UCP1 mRNA in BAT and of UCP2 mRNA in WAT. However, 22 h after exercise, UCP3 mRNA increases observed in skeletal muscles 3 h after exercise returned to sedentary levels. Similar transient increases of UCP3 mRNA were observed in 1 wk treadmill running training or a single exercise bout. In denerved gastrocnemius, GLUT4 and UCP3 mRNA decreased by 58 and 45%, respectively. These data indicate that UCP3 may have a role for fine adjustments of energy expenditure and that up-regulation of UCP3 mRNA may be a defense mechanism against extra energy supply to consume extra energy in skeletal muscles.

Citations

May 6, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C V MusaP Buono
Jan 6, 2000·The Biochemical Journal·D Ricquier, F Bouillaud
Dec 25, 2003·The Proceedings of the Nutrition Society·Patrick Schrauwen, Matthijs Hesselink
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sheila R CostfordMary-Ellen Harper
Jun 6, 2013·Oxidative Medicine and Cellular Longevity·Hajime Otani
Nov 22, 2008·Free Radical Biology & Medicine·Paola VendittiSergio Di Meo
Aug 19, 2008·Biochemical and Biophysical Research Communications·Tomo YonezawaYoshiaki Obara
Mar 27, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·T G Ramsay, M P Richards
Nov 25, 2004·Nutrition·Seiichi KasaokaShigeru Nakajima
Aug 7, 2002·Biochemical and Biophysical Research Communications·Shinobu IkedaOsamu Ezaki
Feb 24, 2010·Biochimica Et Biophysica Acta·Martin Klingenberg
Jan 1, 2010·Cancers·Adamo VallePilar Roca
Mar 17, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P SchrauwenM K C Hesselink
Jun 16, 2004·FEBS Letters·Mary P Thompson, Dongho Kim
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B BuemannA Astrup
Aug 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charles T PutmanDirk Pette
Aug 11, 2005·Pflügers Archiv : European journal of physiology·Luiz Carlos C NavegantesIsis C Kettelhut
Dec 26, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·Y Hatakeyama, P J Scarpace
Jan 26, 2006·American Journal of Physiology. Endocrinology and Metabolism·Sheila R CostfordMary-Ellen Harper
Jan 5, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Véronic BézaireMary-Ellen Harper
Aug 6, 2004·The Proceedings of the Nutrition Society·Patrick Schrauwen, Matthijs K C Hesselink
Aug 21, 2008·American Journal of Physiology. Endocrinology and Metabolism·Sheila R CostfordMary-Ellen Harper
Apr 4, 2009·Journal of Applied Physiology·Annabelle Z CaronGuillaume Grenier
Dec 20, 2007·American Journal of Physiology. Endocrinology and Metabolism·Nobuyo Tsuboyama-KasaokaOsamu Ezaki
Jun 8, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charles T PutmanDirk Pette
Sep 10, 2003·Journal of Applied Physiology·Yoriko MasudaTohru Fushiki
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P SchrauwenM K Hesselink
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patrick SchrauwenMatthijs K C Hesselink
Apr 5, 2000·The Journal of Biological Chemistry·A J Vidal-PuigB B Lowell
Apr 5, 2000·The Journal of Biological Chemistry·D W GongM L Reitman
Mar 4, 2005·Acta Physiologica Scandinavica·P SchrauwenM K C Hesselink

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