uPA and PAI-1 in breast cancer: review of their clinical utility and current validation in the prospective NNBC-3 trial

Advances in Clinical Chemistry
K AnneckeNadia Harbeck

Abstract

The plasminogen activator system is a complex system with multiple interactions and members participating in fibrinolysis, cell migration, angiogenesis, wound healing, embryogenesis, tumor cell dissemination, and metastasis in a variety of solid tumors. Increased levels of uPA and/or PAI-1 in primary tumor tissues of breast cancer patients correlate with tumor aggressiveness and poor clinical outcome. Patients with high tumor tissue antigen content of uPA and/or PAI-1 have a worse probability of disease-free and overall survival than patients with low levels of both of the biomarkers, serving as prognostic markers. The clinical utility of uPA and PAI-1 has been proven on the highest level of evidence (LOE-I). Next to being clinically useful prognostic factors allowing estimates of the course of disease in early breast cancer, uPA and PAI-1 may also serve as predictive factors predicting response to systemic therapy. Node-negative primary breast cancer patients with high uPA/PAI-1 levels benefit significantly from adjuvant chemotherapy. The aim of the ongoing NNBC-3 trial is to determine the benefits of a sequential anthracycline-docetaxel regimen in high-risk node-negative breast cancer patients compared to the current standard...Continue Reading

Citations

Jul 13, 2011·Expert Review of Molecular Diagnostics·Manfred SchmittChristoph Thomssen
Jun 6, 2013·Biomarkers in Medicine·Helge TaubertMatthias Kotzsch
Jun 22, 2012·Experimental Dermatology·R Matthew KleinPaul J Higgins
Dec 2, 2014·Oncology Letters·Zheng LiIsabelle Gabelle-Flandin
Jul 30, 2015·Oncotarget·David Z Kochan, Olga Kovalchuk
Apr 28, 2016·Antioxidants & Redox Signaling·Deepika RamanShazib Pervaiz
Jun 19, 2009·Journal of the National Cancer Institute·Christoph ThomssenMartina Vetter
Oct 23, 2010·Expert Review of Molecular Diagnostics·Karin MengeleManfred Schmitt
Apr 6, 2012·Breast Cancer Research and Treatment·Su-Hyeong KimShivendra V Singh
Jul 10, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Gordana Horvatic HercegDrago Prgomet
Aug 26, 2016·Contrast Media & Molecular Imaging·Christel VangestelSteven Staelens
Nov 18, 2019·Cancer Metastasis Reviews·Marta Helena Kubala, Yves Albert DeClerck
Sep 12, 2012·Journal of Molecular Endocrinology·Lacey M Litchfield, Carolyn M Klinge
Sep 12, 2012·Breast Cancer Research and Treatment·Joomin LeeShivendra V Singh
Dec 17, 2008·Breast Cancer Research and Treatment·Antonio Llombart-Cussac
Dec 30, 2009·Breast Cancer Research and Treatment·Simona BorstnarTanja Cufer
Aug 20, 2009·The Journal of Biological Chemistry·Guoqiang ZhangAllison A Eddy
Jan 1, 2009·Journal of Oncology·Jennifer FreytagPaul J Higgins
Jul 23, 2011·Breast Care·Florian Schuetz
Nov 26, 2008·Journal of Mammary Gland Biology and Neoplasia·Claire M Perks, Jeff M P Holly
Jan 16, 2014·Annual Review of Medicine·Costanza Paoletti, Daniel F Hayes
Oct 9, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Simone EdelmannNicolas Mermod
Feb 7, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Catherine DugganAnne McTiernan
May 15, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marie KlintmanMitch Dowsett
Feb 23, 2010·Journal of Proteome Research·Sandra RauserAxel Walch
Jun 18, 2010·Cancer Treatment Reviews·Nadia HarbeckCornelia Liedtke
Oct 10, 2021·Gynécologie, Obstétrique, Fertilité & Sénologie·P ManiezC Mathelin
Jun 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sijing LiLi Sun

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