Upcoming biomarkers for the diagnosis of Kawasaki disease: A review

Clinical Biochemistry
Pavithra ParthasarathyTapas K Mondal

Abstract

Kawasaki disease (KD) is a major cause of acquired heart disease among children and increases the risk of myocardial infarction. While the biochemical basis of the disease is unclear, the evidence suggests interplay between a microbial infection and a genetic predisposition in the development of the disease. Diagnosis of KD based on clinical observation is not completely reliable and is problematic due to the time-sensitive nature of the disease. Hence, identification of inflammatory, proteomic, and genetic biomarkers may assist in earlier and more effective diagnosis and treatment. This review of observational studies and clinical trials analyzes biomarkers in recent research that may be used to establish a gold standard test for KD diagnosis. 65 articles in the literature are assessed to investigate these new biomarkers in addition to biomarkers presently in use. ESR≥40mm/h, leukocyte count ≥16∗10(9)/L and increased WBC count are together suggestive of the presence of KD. Among proteomic biomarkers, elevated NT-proBNP and differing levels of several other proteomic biomarkers such as iNOS in monocytes and neutrophils have been observed in KD patients. Genetic polymorphisms of six HLA class I genes have also been linked with t...Continue Reading

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Sep 8, 2016·Annals of the New York Academy of Sciences·Xavier RodóJosep-Anton Morguí
Sep 4, 2016·Expert Review of Clinical Immunology·Shreya Agarwal, Devendra K Agrawal
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May 11, 2021·Frontiers in Pediatrics·Kan HuijuanYan Wenhua
Jun 29, 2021·Frontiers in Pediatrics·Caterina Matucci-CerinicAngelo Ravelli

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