Upcoming therapeutic targets in cutaneous lupus erythematous

Expert Review of Clinical Pharmacology
Anna Sophie Klaeschen, J Wenzel

Abstract

Novel insights into molecular mechanisms have altered our understanding of the pathogenesis of autoimmune skin disorders. Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease characterized by auto-aggressive skin inflammation which histologically presents with interface dermatitis. This inflammation is driven by interferon (IFN)-regulated proinflammatory cytokines that orchestrate the B- and T-cell mediated lesional inflammation. During the last years, therapeutic strategies have focused on these players: biologicals targeting type I IFNs and their receptors as well as anti-B-cell drugs have been investigated in clinical trials with variable success. Very recently, CLE gene expression analyses revealed lesional activation of several pathways of the immune system, thus providing potential new therapeutic targets. In this article, we review the current knowledge concerning pathways and key mediators involved in the pathogenesis of cutaneous lupus erythematosus (including TLR-dependent and TLR-independent immune activation, NfkB, TBK1, PI3K, MAPK, JAK/STAT-pathway) and their inhibitors (e.g. chloroquine, bufalin, duvelisib, rapamycin, R788, KN-93, amlexanox, tofacitinib, ruxolitinib, baricitinib), and discuss emerging...Continue Reading

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Citations

May 23, 2017·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Nesrine ElloumiHatem Masmoudi
Mar 30, 2017·The Journal of Investigative Dermatology·Benedikt ScholtissekJoerg Wenzel
Dec 27, 2016·The Journal of Dermatological Treatment·Aniseh SamadiAlireza Firooz

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