Upconversion-Magnetic Carbon Sphere for Near Infrared Light-Triggered Bioimaging and Photothermal Therapy

Theranostics
Jiaxin WangLining Sun

Abstract

Nanoparticle-based theranostics combines tumor imaging and cancer therapy in one platform, but the synthesis of theranostic agents is impeded by chemical groups on the surface and the size and morphology of the components. Strategies to construct a multifunctional platform for bioimaging and photothermal therapy (PTT) are urgently needed. A new upconversion-magnetic agent (FeCUPs) based on hollow carbon spheres, which is both a photothermal agent and a dual carrier of luminescent and magnetic nanoparticles, provides an effective approach for tumor elimination. Methods: The morphology of FeCUPs was characterized for the construction and size adjustment of the theranostic agent using transmission electron microscopy, high-resolution transmission electron microscopy, energy dispersive spectroscopy and high angle annular dark field scanning transmission electron microscopy. The distribution of FeCUPs was tracked under in-situ upconversion luminescence (UCL) imaging and magnetic resonance imaging (MRI) in vivo. Photothermal therapy was carried out on tumor-bearing mice, after which the toxicity of PTT was evaluated by a blood biochemistry test and histological section analysis. Results: Stable and uniform loading of luminescent nano...Continue Reading

Citations

Aug 19, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lile DongGuobin Hong
Sep 29, 2020·International Journal of Nanomedicine·Yun-Jing HouHong-Xue Meng
Aug 15, 2020·Frontiers in Chemistry·Fangfang LiuJinliang Liu
Mar 4, 2021·Journal of Nanoscience and Nanotechnology·Maria MonteserínL Francisco Martín
Mar 27, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Namdev DhasTejal Mehta
May 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Snigdharani PandaSasmita Mohapatra

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Methods Mentioned

BETA
electron diffraction
transmission electron microscopy
dynamic light scattering
oncotherapy

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