Upconverting Nanoparticles Prompt Remote Near-Infrared Photoactivation of Ru(II)-Arene Complexes

Chemistry : a European Journal
E RuggieroL Salassa

Abstract

The synthesis and full characterisation (including X-ray diffraction studies and DFT calculations) of two new piano-stool Ru(II) -arene complexes, namely [(η(6) -p-cym)Ru(bpy)(m-CCH-Py)][(PF)6]2 (1) and [(η(6) -p-cym)Ru(bpm)(m-CCH-Py)][(PF)6]2 (2; p-cym=p-cymene, bpy=2,2'-bipyridine, bpm=2,2'-bipyrimidine, and m-CCH-Py=3-ethynylpyridine), is described and discussed. The reaction of the m-CCH-Py ligand of 1 and 2 with diethyl-3-azidopropyl phosphonate by Cu-catalysed click chemistry affords [(η(6) -p-cym)Ru(bpy)(P-Trz-Py)][(PF)6]2 (3) and [(η(6) -p-cym)Ru(bpm)(P-Trz-Py)][(PF)6]2 (4; P-Trz-Py=[3-(1-pyridin-3-yl-[1,2,3]triazol-4-yl)-propyl]phosphonic acid diethyl ester). Upon light excitation at λ=395 nm, complexes 1-4 photodissociate the monodentate pyridyl ligand and form the aqua adduct ions [(η(6) -p-cym)Ru(bpy)(H2O)](2+) and [(η(6) -p-cym)Ru(bpm)(H2O)](2+). Thulium -doped upconverting nanoparticles (UCNPs) are functionalised with 4, thus exploiting their surface affinity for the phosphonate group in the complex. The so-obtained nanosystem UCNP@4 undergoes near-infrared (NIR) photoactivation at λ=980 nm, thus producing the corresponding reactive aqua species that binds the DNA-model base guanosine 5'-monophosphate.

References

May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
Jul 21, 2004·Journal of Computational Chemistry·Eric F PettersenThomas E Ferrin
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fuyi WangPeter J Sadler
Jun 14, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Marco MontaltiUmberto Tonellato
Sep 13, 2007·Journal of Computational Chemistry·Noel M O'BoyleKarol M Langner
Jun 24, 2008·Journal of the American Chemical Society·Brant C BorenValery V Fokin
Jan 20, 2009·Seminars in Cutaneous Medicine and Surgery·Daniel Barolet
Jun 10, 2009·Frontiers in Neural Circuits·Elodie FinoRafael Yuste
Oct 9, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·John-Christopher BoyerFrank C J M van Veggel
Oct 30, 2009·Chemical Communications : Chem Comm·Soledad Betanzos-LaraPeter J Sadler
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Nicola J FarrerPeter J Sadler
Sep 21, 2010·Chemistry : a European Journal·Alexander K Tucker-Schwartz, Robin L Garrell
Oct 19, 2010·Journal of the American Chemical Society·John-Christopher BoyerNeil R Branda
Nov 17, 2010·Journal of Medicinal Chemistry·Gilles GasserNils Metzler-Nolte
Jun 1, 2011·Angewandte Chemie·Markus Haase, Helmut Schäfer
Oct 20, 2011·Chemical Society Reviews·Jing ZhouFuyou Li
Feb 22, 2012·Chemistry : a European Journal·John-Christopher BoyerNeil R Branda
Aug 22, 2012·Chemical Communications : Chem Comm·Erin WachterEdith C Glazer
Jul 4, 2013·Journal of the American Chemical Society·Mark A SgambelloneClaudia Turro
Nov 20, 2013·Journal of the American Chemical Society·Peter T BurksPeter C Ford
Jan 8, 2014·Chemical Communications : Chem Comm·E RuggieroL Salassa
Aug 13, 2014·Chemical Society Reviews·Yun SunFuyou Li
Nov 20, 2014·Chemical Communications : Chem Comm·Shuqing HeSi Wu
Dec 11, 2014·Chemical Reviews·Jing ZhouFuyou Li
Dec 24, 2014·Chemical Communications : Chem Comm·Agustin E PierriPeter C Ford
Dec 24, 2014·Chemical Communications : Chem Comm·Emmanuel RuggieroLuca Salassa
Sep 22, 2015·Advanced Materials·Si Wu, Hans-Jürgen Butt

❮ Previous
Next ❯

Citations

Feb 14, 2017·Journal of the American Chemical Society·Mahdi KarimiMichael R Hamblin
Aug 3, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Emmanuel RuggieroLuca Salassa
Oct 7, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Ming HuBengang Xing
Jun 29, 2018·Nanoscale·Lucía Labrador-PáezDaniel Jaque
Jul 7, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Sylvestre Bonnet
Jul 12, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Laura A HagerAlessio Terenzi
Aug 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana I Benítez-MateosFernando López-Gallego
Nov 23, 2018·Scientific Reports·Silvia Alonso-de CastroLuca Salassa
Jul 2, 2020·Advanced Drug Delivery Reviews·David C LutherVincent M Rotello
Aug 8, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Michael S MeijerSylvestre Bonnet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.