PMID: 7547335Jan 1, 1995Paper

Update in allergy testing in childhood asthma: how do you know whether you are successfully controlling the patient's inflammation?

Pediatric Pulmonology. Supplement
S AhlstedtI Enander

Abstract

The levels of serum eosinophil cationic protein (ECP) in asthmatic patients have been shown to be increased in acute and undertreated asthma as a result of inflammation. ECP is released during in vitro clotting of peripheral blood. The exposure of the atopic individual to an offending allergen stimulates the activation of the blood eosinophils and their release of ECP into serum. Serum ECP levels reflect avoidance of the allergen, and successful treatment of asthma inflammation with corticosteroids cause a reduction of the inflammation in the lung. When individual patients with asthma are followed, the level of serum ECP can be used (1) as an early indicator of the degree of inflammation, (2) for monitoring the efficacy of corticosteroid therapy, and (3) for possible noncompliance with treatment.

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Citations

Dec 26, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·T P Sollecito, G Tino
Jan 27, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·A PrehnF H Sennhauser
Feb 10, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Slavica DodigRenata Zrinski-Topić
May 5, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·H Z KamfarW A Milaat

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