PMID: 9664158Jul 17, 1998Paper

Update of gp130 cytokines in multiple myeloma

Current Opinion in Hematology
B Klein

Abstract

Interleukin (IL)-6 plays a major role in the control of the survival and proliferation of myeloma cell lines and primary myeloma cells. The genes of the receptors of IL-6 have been cloned, and the major signaling pathways involved in gp130 IL-6 transducer activation have been identified. In addition, another five cytokines that activate the gp130 IL-6 transducer have been identified. We review the recent data on gp130 cytokines and gp130-mediated signal transduction, their involvement in myeloma cell biology, and we discuss the possible therapeutic applications of this knowledge.

Citations

May 19, 2000·Cell Biology International·K GadóA Falus
May 7, 2002·Nature Reviews. Cancer·W Michael Kuehl, P Leif Bergsagel
Dec 21, 2000·British Journal of Haematology·T OtsukiA Ueki
Jun 5, 1997·The New England Journal of Medicine·R Bataille, J L Harousseau
May 19, 2011·Biochemistry. Biokhimii︠a︡·M N Kostjukova, N N Tupitsyn
Jun 1, 1999·Leukemia & Lymphoma·B KleinJ F Rossi
May 3, 2002·Blood·Anne-Tove BrenneHenrik Hjorth-Hansen
Jun 17, 2000·Endocrine Reviews·C J Auernhammer, S Melmed
Dec 6, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N G KastrinakisC Kittas

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