Update of the results of the Spanish branch of the European Randomized Study on Screening for Prostate Cancer (ERSPC)

Actas urologicas españolas
M LujánA Berenguer

Abstract

The role of prostate cancer (PC) screening is currently being questioned. The objective of the European Randomized Study of Screening for Prostate Cancer (ERSPC) was to demonstrate whether PC screening reduced mortality from this disease. The results from the Spanish branch of this study are presented: all-cause and cancer-specific mortality, the characteristics of the detected tumors, primary treatments and progression to advanced disease. A total of 18,612 men, between the ages of 45 and 70, were invited to participate in the study, excluding those with a life expectancy of less than 10 years. The men were randomized to the screening arm (serum prostate-specific antigen [PSA] reading) or the control arm (no diagnostic tests). Randomized transrectal ultrasound-guided sextant prostate biopsies were indicated for the men in the screening arm with PSA levels ≥3ng/ml. The detected PCs were identified (stage and primary treatment), as well as the deaths that occurred (date and cause of death). The study was performed with 4276 men (2415 in the screening arm and 1861 in the control arm). The median age and serum PSA level were 57 years and 0.90ng/mL, respectively. The median follow-up time was 15.8 years. A total of 242 PCs were dia...Continue Reading

References

Mar 6, 2009·The Lancet Oncology·Hans-Hermann Dubben
Sep 10, 2009·International Journal of Cancer. Journal International Du Cancer·Tineke WoltersFritz H Schröder
Mar 13, 2013·Journal of the National Cancer Institute·Tuomas P KilpeläinenAnssi Auvinen
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 13, 2014·Actas urologicas españolas·F Gómez-VeigaM Emberton

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Citations

Mar 11, 2016·Semergen·F J Brenes Bermúdez, A Alcántara Montero
Jun 5, 2016·Actas urologicas españolas·J M Martínez-JabaloyasUNKNOWN Grupo Español de Cáncer de Próstata
Jun 22, 2016·Current Opinion in Urology·Sigrid V Carlsson, Monique J Roobol

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