Update of TTD: Therapeutic Target Database.

Nucleic Acids Research
Feng ZhuYuZong Chen

Abstract

Increasing numbers of proteins, nucleic acids and other molecular entities have been explored as therapeutic targets, hundreds of which are targets of approved and clinical trial drugs. Knowledge of these targets and corresponding drugs, particularly those in clinical uses and trials, is highly useful for facilitating drug discovery. Therapeutic Target Database (TTD) has been developed to provide information about therapeutic targets and corresponding drugs. In order to accommodate increasing demand for comprehensive knowledge about the primary targets of the approved, clinical trial and experimental drugs, numerous improvements and updates have been made to TTD. These updates include information about 348 successful, 292 clinical trial and 1254 research targets, 1514 approved, 1212 clinical trial and 2302 experimental drugs linked to their primary targets (3382 small molecule and 649 antisense drugs with available structure and sequence), new ways to access data by drug mode of action, recursive search of related targets or drugs, similarity target and drug searching, customized and whole data download, standardized target ID, and significant increase of data (1894 targets, 560 diseases and 5028 drugs compared with the 433 tar...Continue Reading

References

Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Aug 24, 1999·Journal of Molecular Biology·T C Wood, W R Pearson
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·E H OhlsteinJ D Elliott
Dec 26, 2001·Nucleic Acids Research·X ChenY Z Chen
Oct 17, 2002·Journal of Molecular Biology·Patrice Koehl, Michael Levitt
Jan 2, 2003·Nature Reviews. Drug Discovery·Brian P Zambrowicz, Arthur T Sands
Oct 4, 2003·Nature Reviews. Drug Discovery·Mark A Lindsay
Nov 3, 2004·Nature Reviews. Drug Discovery·Richard Kramer, Dalia Cohen
May 3, 2005·Nature Reviews. Drug Discovery·Daniel C Liebler, F Peter Guengerich
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Cosmas GiallourakisVamsi K Mootha
Dec 31, 2005·Nucleic Acids Research·David S WishartJennifer Woolsey
Jan 18, 2006·Annual Review of Medicine·Michel EichelbaumWilliam E Evans
Oct 4, 2006·Nature Reviews. Drug Discovery·Peter ImmingAchim Meyer
Dec 2, 2006·Nature Reviews. Drug Discovery·John P OveringtonAndrew L Hopkins
Dec 13, 2006·Journal of Medicinal Chemistry·Jonas BoströmStefan Schmitt
Dec 13, 2006·Journal of Medicinal Chemistry·Niu HuangJohn J Irwin
Dec 19, 2006·Molecular Biotechnology·Kenneth Lundstrom
Jan 3, 2007·Drug Discovery Today·Grant R ZimmermannCurtis T Keith
Sep 28, 2007·Current Medicinal Chemistry·Ranadhir DeyBhaskar Saha
Oct 9, 2007·Nature Biotechnology·Muhammed A YildirimMarc Vidal
Dec 1, 2007·Nucleic Acids Research·David S WishartMurtaza Hassanali
Feb 20, 2008·BMC Bioinformatics·Zhenting GaoHualiang Jiang
Oct 22, 2008·Nature Chemical Biology·Andrew L Hopkins
Jan 9, 2009·Current Drug Targets·Guy Barros BarcellosWalter Filgueira de Azevedo
Jan 31, 2009·Nature Reviews. Drug Discovery·Jia JiaYu Zong Chen
Apr 11, 2009·Science·Gregory M Lee, Charles S Craik
Jun 6, 2009·Annual Review of Biochemistry·Aled Edwards

❮ Previous
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Citations

Sep 24, 2011·Chemical Reviews·Shankar SubramaniamMano Ram Maurya
Oct 15, 2013·Nature Methods·Malachi GriffithRichard K Wilson
Jul 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Feng ZhuYuzong Chen
Feb 15, 2011·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Liat PerlmanRoded Sharan
Mar 29, 2011·Briefings in Bioinformatics·V Joachim Haupt, Michael Schroeder
Jan 17, 2012·Bioinformatics·Christian SengerStefan Günther
Nov 10, 2010·Nucleic Acids Research·Craig KnoxDavid S Wishart
Nov 26, 2010·Nucleic Acids Research·Hao YeZhiwei Cao
Nov 15, 2011·Nucleic Acids Research·Michael KuhnPeer Bork
Nov 26, 2011·Nucleic Acids Research·María P MagariñosFernán Agüero
Nov 10, 2011·Nucleic Acids Research·Nikolai HeckerRobert Preissner
Nov 24, 2011·Nucleic Acids Research·Krzysztof KuchtaJoanna Krwawicz
May 4, 2012·Journal of the Royal Society, Interface·Jennifer L LahtiRuss B Altman
Feb 10, 2011·BMC Bioinformatics·Nobuyoshi Sugaya, Toshio Furuya
Aug 21, 2012·BMC Bioinformatics·Jingchun SunZhongming Zhao
Dec 7, 2013·BMC Genomics·Ravi V AtreyaZhongming Zhao
Jan 10, 2013·PLoS Computational Biology·David S Wishart
Feb 20, 2014·PLoS Computational Biology·Tapesh SantraBoris N Kholodenko
Mar 21, 2012·PloS One·Sree Krishna ChanumoluRajinder S Chauhan
Jun 28, 2013·PloS One·V Joachim HauptMichael Schroeder
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Gui-Biao ZhangShi-Bing Su
Aug 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ming YangGuang Ji
Apr 3, 2012·Pharmacogenetics and Genomics·Henrik Berg Rasmussen, Christina Mackeprang Dahmcke
Jun 10, 2011·Journal of Postgraduate Medicine·B M Padhy, Y K Gupta
Apr 28, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Simone DaminelliMichael Schroeder
Dec 14, 2011·Drug Discovery Today·Isabella GashawKhusru Asadullah
Sep 29, 2011·Drug Discovery Today·Isabella GashawKhusru Asadullah
Sep 11, 2010·Forensic Science International : Synergy·Frank MusshoffBurkhard Madea
Jun 18, 2010·Current Opinion in Biotechnology·Edda KlippUrsula Kummer
Aug 13, 2011·Journal of Chemical Information and Modeling·Tiejun ChengStephen H Bryant
Nov 30, 2012·Journal of Cellular Biochemistry·Xiuping Chen
Aug 28, 2014·Drug Development Research·Da Cheng Hao, Pei Gen Xiao
Nov 19, 2015·Journal of Cheminformatics·Saber A AkhondiJan A Kors

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Software Mentioned

BLAST
TTD
MODEL
PDTD

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