Update on APOA5 Genetics: Toward a Better Understanding of Its Physiological Impact

Current Atherosclerosis Reports
Montse Guardiola, Josep Ribalta

Abstract

This review is intended to summarize the genetic studies published during the last 3 years that help us understand the physiology of apoAV and its clinical implications. APOA5 is probably the gene with the strongest effect on triglyceride (TG) metabolism. APOA5 is almost exclusively expressed in the liver, and its product apoAV has a very low circulating concentration. New physiological roles of apoAV have been recently elucidated, such as control of chylomicron production in the intestine and TG accumulation in adipose tissue. The key role of APOA5 in TG metabolism has been largely shown through genetic studies in association with either severe or moderate hypertriglyceridemia. Studies suggest that APOA5 variants affect not only total TG concentrations but also the entire lipoprotein subclass distribution, shifting them toward atherogenic dyslipidemia in high-risk subjects. Environmental interactions and epigenetic factors are also crucial in regulating these processes. Delineation of the mechanisms involved in the transcriptional control of the gene, combined with determination of biological significance of the SNPs in the APOA5 locus, would help to fully understand the effect of APOA5 on TGs. In summary, APOA5 variants cause...Continue Reading

References

Sep 29, 2001·The Journal of Biological Chemistry·H N van der VlietR A Chamuleau
Jun 9, 2005·The Journal of Biological Chemistry·Philippa J TalmudSteve E Humphries
May 9, 2006·Current Opinion in Lipidology·Martin AdielsJan Borén
Apr 27, 2007·Journal of Lipid Research·Xiao ShuTrudy M Forte
Aug 6, 2010·Nature·Tanya M TeslovichSekar Kathiresan
Apr 15, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M GuardiolaJ Ribalta
Apr 20, 2011·Circulation·Michael MillerUNKNOWN Council on the Kidney in Cardiovascular Disease
Oct 20, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yi-Jan HuangJau-Tsuen Kao
Jan 14, 2012·Journal of Internal Medicine·R P SurendranG M Dallinga-Thie
Jan 12, 2013·Journal of Lipid Research·Elena Mendoza-BarberáFrancisco Blanco-Vaca
Mar 13, 2013·Genetics and Molecular Research : GMR·T K FuruyaM A C Smith
May 17, 2013·The Journal of Clinical Investigation·Jon C GonzalesJeffrey D Esko
Oct 8, 2013·Nature Genetics·Cristen J WillerUNKNOWN Global Lipids Genetics Consortium
Dec 3, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jesús M Martín-CamposFrancisco Blanco-Vaca
Dec 18, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Benoit J ArsenaultJean-Claude Tardif
Mar 5, 2014·Annals of Clinical Biochemistry·Amanda J HooperJohn R Burnett
Mar 19, 2014·Lancet·Katherine J DickNilesh J Samani
Apr 15, 2014·Cardiovascular Diabetology·Jeremy N AdamsDonald W Bowden
May 6, 2014·Journal of Clinical Lipidology·Neema ChokshiAbhimanyu Garg
Jun 14, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Makoto AraiMinoru Okubo
Sep 17, 2014·Journal of Lipid Research·Christopher B ColeRuth McPherson

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Citations

Sep 19, 2019·Molecular Nutrition & Food Research·Jennifer M KellySarah L Booth
Nov 15, 2017·Current Opinion in Lipidology·Laurence D ParnellChao-Qiang Lai
Aug 15, 2020·Frontiers in Endocrinology·Jacqueline S Dron, Robert A Hegele
Feb 27, 2020·PloS One·Paul T Williams
Apr 5, 2021·Journal of Lipid Research·Sander Kersten

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