Update on Endothelin Receptor Antagonists in Hypertension

Current Hypertension Reports
Michel Burnier

Abstract

To review the most recent data on the development of endothelin receptor antagonists (ERAs) for the treatment of hypertension and the management of diabetic nephropathy RECENT FINDINGS: Recent reviews and meta-analyses of experimental and clinical data obtained with ERAs confirmed that endothelin receptor blockade is associated with significant decreases in blood pressure in essential hypertension but also in resistant hypertension. In addition, in patients with diabetic nephropathy, ERAs induce significant 30-40% decreases in albuminuria when administered on top of blockers of the renin-angiotensin system. Yet, the benefits of ERAs have often been limited by their tolerability profile, essentially fluid retention and the development of edema and liver toxicity. Hence, several programs have been interrupted. Today, only one ERA, aprocitentan, is still under development for the treatment of resistant hypertension. Regarding the place of ERAs in the management of diabetic nephropathy, the results of the SONAR trial with atrasentan are eagerly awaited but the recent interruption of this trial because of insufficient events is worrisome, as one might not obtain all the expected information for this major trial. Blockade of endothel...Continue Reading

References

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Citations

Sep 10, 2019·Hypertension·Michel AziziJean-Sébastien Hulot
Jan 10, 2020·Current Hypertension Reports·Wilbert S Aronow
Aug 28, 2020·Frontiers in Pediatrics·Monique RadmanJerry Zimmerman
Dec 15, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Qiannan GaoJun Cai
May 19, 2021·Journal of Cardiovascular Pharmacology·Emily K McCoy, Katelin M Lisenby
Dec 16, 2021·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Aikaterini DamianakiMichel Burnier

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