Update on Foregut Molecular Embryology and Role of Regenerative Medicine Therapies

Frontiers in Pediatrics
Silvia PerinNikhil Thapar

Abstract

Esophageal atresia (OA) represents one of the commonest and most severe developmental disorders of the foregut, the most proximal segment of the gastrointestinal (GI) tract (esophagus and stomach) in embryological terms. Of intrigue is the common origin from this foregut of two very diverse functional entities, the digestive and respiratory systems. OA appears to result from incomplete separation of the ventral and dorsal parts of the foregut during development, resulting in disruption of esophageal anatomy and frequent association with tracheo-oesophageal fistula. Not surprisingly, and likely inherent to OA, are associated abnormalities in components of the enteric neuromusculature and ultimately loss of esophageal functional integrity. An appreciation of such developmental processes and associated defects has not only enhanced our understanding of the etiopathogenesis underlying such devastating defects but also highlighted the potential of novel corrective therapies. There has been considerable progress in the identification and propagation of neural crest stem cells from the GI tract itself or derived from pluripotent cells. Such cells have been successfully transplanted into models of enteric neuropathy confirming their ab...Continue Reading

References

Oct 1, 1977·Annals of Surgery·M B OrringerH Sloan
Apr 1, 1984·Surgery, Gynecology & Obstetrics·T C PutnamW J Klish
Jul 4, 1998·Mechanisms of Development·J J Gibson-BrownV E Papaioannou
Sep 10, 1998·Nature Genetics·Y LitingtungC Chiang
Feb 18, 1999·Journal of Pediatric Surgery·C A CriseraG K Gittes
Jun 1, 2000·Development, Growth & Differentiation·B Q Qi, S W Beasley
Dec 4, 2001·Genes & Development·P W Ingham, A P McMahon
Jan 31, 2002·Journal of Pediatric Surgery·Adonis S IoannidesAndrew J Copp
Dec 28, 2002·American Journal of Medical Genetics·Pascal de Santa BarbaraDrucilla Jane Roberts
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
Apr 30, 2003·Journal of Pediatric Surgery·Aayed R Al-QahtaniSandeep K Mayer
Jun 5, 2003·Journal of Pediatric Surgery·D C LittleS A Engum
Dec 24, 2004·Journal of Pediatric Surgery·Dejan ArsicSpencer Beasley
Jul 20, 2005·Developmental Biology·Mercè MartínGérard Gradwohl
Jan 24, 2006·Developmental Biology·Tushar J DesaiWellington V Cardoso
Jun 6, 2006·Genes & Development·Karl Willert, Katherine A Jones
Jun 30, 2006·Developmental Biology·Zengxin WangKaren Niederreither
Sep 16, 2006·Digestive Diseases and Sciences·Khalid M KhanJohn E Foker
Oct 3, 2006·Journal of Pediatric Surgery·Lewis Spitz
Nov 2, 2006·Advances in Experimental Medicine and Biology·Richard B AndersonHeather M Young
Jan 30, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yina LiChin Chiang
Oct 29, 2008·The Journal of Thoracic and Cardiovascular Surgery·Yuen NakaseAkeo Hagiwara
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kelley S Harris-JohnsonXin Sun
Aug 5, 2010·American Journal of Medical Genetics. Part a·Benjamin D SolomonDerek A T Cummings

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Citations

Aug 23, 2019·American Journal of Medical Genetics. Part a·Sushma GupthaAngela E Scheuerle
Apr 17, 2020·Birth Defects Research·Chantal A Ten KateErwin Brosens
Apr 19, 2020·Journal of Tissue Engineering and Regenerative Medicine·Caleb D Vogt, Angela Panoskaltsis-Mortari
Apr 20, 2019·Nature Reviews. Disease Primers·Marinde van LennepMichiel P van Wijk
Aug 22, 2021·Abdominal Radiology·Darshan GandhiArpit Nagar

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Methods Mentioned

BETA
transgenic

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