Update on Gastroesophageal Adenocarcinoma Targeted Therapies

Hematology/oncology Clinics of North America
Steven B Maron, Daniel V T Catenacci

Abstract

Gastroesophageal cancer (GEC) remains a major cause of cancer-related mortality worldwide. Although the incidence of distal gastric adenocarcinoma (GC) is declining in the United States, proximal esophagogastric junction adenocarcinoma (EGJ) incidence is rising. GC and EGJ, together, are treated uniformly in the metastatic setting as GEC. Overall survival in the metastatic setting remains poor, with few molecular targeted approaches having been successfully incorporated into routine care to date-only first-line anti-HER2 therapy for ERBB2 amplification and second-line anti-VEGFR2 therapy. This article reviews aberrations in epidermal growth factor receptor, MET, and ERBB2, their therapeutic implications, and future directions in targeting these pathways.

Citations

Jun 22, 2018·Oncotarget·Aafke CreemersHanneke W M van Laarhoven
Aug 7, 2018·World Journal of Gastrointestinal Oncology·Stavros GkolfinopoulosPanteleimon Kountourakis
Aug 21, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven B MaronDaniel V T Catenacci
Feb 26, 2021·Frontiers in Molecular Biosciences·Kate DinneenOrla Sheils
Mar 26, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ivonne HaffnerFlorian Lordick
Dec 11, 2017·The Annals of Thoracic Surgery·Alexei A GoltsovWayne L Hofstetter

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