Update on mantle cell lymphoma.

Blood
Kami Maddocks

Abstract

Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma that is most commonly treated with combination chemo-immunotherapy at diagnosis because of the poor prognosis. More indolent presentations have been described including patients who can defer initial therapy without adverse impact on survival. The 2016 World Health Organization updated classification describes 2 major subtypes, classical and leukemic nonnodal MCL, each with unique molecular features and clinical presentations. Although there is no standard of care for MCL, aggressive chemo-immunotherapy regimens containing rituximab and cytarabine, followed by consolidation with autologous stem cell transplantation and maintenance rituximab, are the most used approach in young fit patients, and chemo-immunotherapy, followed by rituximab maintenance, is most commonly used in older patients. Despite the improvement in response durations with currently available therapies, patients will inevitably relapse. A number of targeted therapies are approved in the relapsed setting and are now under evaluation in combination with standard frontline therapy. Although the approval of ibrutinib changed the landscape of therapy for relapsed MCL, prognosis remains poor after p...Continue Reading

References

Aug 2, 2003·European Journal of Haematology·Niels S AndersenUNKNOWN Nordic Lymphoma Group
Jan 27, 2004·The American Journal of Pathology·Antonio MartinezDolors Colomer
Dec 23, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andre GoyAlma M Rodriguez
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mathias J RummelParis S Mitrou
Sep 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jorge E RomagueraFernando F Cabanillas
Nov 1, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F MorschhauserC Dumontet
Oct 27, 2007·Blood·Eva HosterUNKNOWN European Mantle Cell Lymphoma Network
Jan 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Devin CoonRohit Bhargava
Jul 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K Sue RobinsonBruce D Cheson
Dec 17, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoyR I Fisher
Feb 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter MartinJohn P Leonard
Feb 28, 2009·British Journal of Haematology·Thomas M HabermannJoseph M Tuscano
Jul 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Georg HessBertrand Coiffier
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carlo ViscoFrancesco Rodeghiero
Mar 19, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S H BernsteinR I Fisher
Jun 21, 2013·The New England Journal of Medicine·Michael L WangKristie A Blum
Sep 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andre GoyThomas E Witzig
Sep 14, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P L ZinzaniT E Witzig
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James N KochenderferSteven A Rosenberg
Feb 26, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C Y CheahM L Wang
Mar 5, 2015·The New England Journal of Medicine·Tadeusz RobakUNKNOWN LYM-3002 Investigators
May 30, 2015·Blood·Marie-Hélène Delfau-LarueUNKNOWN European Mantle Cell Lymphoma Network
Nov 5, 2015·The New England Journal of Medicine·Jia RuanJohn P Leonard
Jan 15, 2016·Blood·Peter MartinKristie A Blum
Feb 24, 2016·The Lancet Oncology·Marek TrněnýUNKNOWN SPRINT trial investigators and in collaboration with the European Mantle Cell Lymphoma Network
Mar 2, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eva HosterWolfram Klapper

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Citations

Jan 18, 2019·American Journal of Hematology·Adam Levin, Nirav N Shah
Feb 28, 2019·Current Hematologic Malignancy Reports·Jennifer Crombie, Philippe Armand
Feb 23, 2019·British Journal of Haematology·Filip MundtAgata M Wasik
Sep 14, 2019·Journal of Cellular and Molecular Medicine·Olga BabosovaLucie Lanikova
Nov 27, 2019·Cancers·Domenico AlbanoUNKNOWN Young Italian Association of Nuclear Medicine
Jul 10, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Marius E MayerhoeferHeiko Schöder
Aug 3, 2020·Current Opinion in Oncology·Marie José KerstenCatherine Thieblemont
Nov 11, 2019·Abdominal Radiology·Abdelrahman K HanafyKhaled M Elsayes
Aug 11, 2020·Expert Opinion on Investigational Drugs·Sebastian Torke, Martin S Weber
Apr 1, 2019·Annals of Nuclear Medicine·Domenico AlbanoFrancesco Bertagna
Feb 6, 2020·International Journal of Molecular Sciences·Anuvrat SircarNarendranath Epperla
Jun 27, 2019·Journal of Investigative Medicine High Impact Case Reports·Elvira UmyarovaVenu Madhav Konala
Mar 19, 2020·Journal of Hematology & Oncology·Dok Hyun YoonWon Seog Kim
Jan 23, 2021·Clinical Lymphoma, Myeloma & Leukemia·Swetha KambhampatiCharalambos B Andreadis
Mar 7, 2021·International Journal of Molecular Sciences·Viktoria FuhrHilka Rauert-Wunderlich
Mar 20, 2021·Scientific Reports·Morten P OksvoldThea Kristin Våtsveen
Aug 31, 2020·Hematology/oncology Clinics of North America·Christina Lee, Peter Martin
Apr 22, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Esther S FrischMartin S Weber
May 10, 2021·Transplantation and Cellular Therapy·Farah YassineMohamed A Kharfan-Dabaja
Mar 1, 2021·Acta Gastro-enterologica Belgica·F LifrangeP Demetter
Jun 10, 2020·Cancer Cell·Craig S Sauter, Renier J Brentjens
Mar 20, 2021·The American Journal of Surgical Pathology·Mariko YabeAhmet Dogan
Jun 11, 2021·Blood·Michael E Williams
Jun 18, 2021·The Annals of Otology, Rhinology, and Laryngology·Christopher T BreenNikita Kohli
Jun 22, 2021·Blood Advances·Constantine S TamJudith Trotman
Aug 8, 2021·International Journal of Molecular Sciences·Aikaterini Poulaki, Stavroula Giannouli

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