Update on NAFLD genetics: From new variants to the clinic.

Journal of Hepatology
Eric Trépo, Luca Valenti

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-income countries and the burden of NAFLD is increasing at an alarming rate. The risk of developing NAFLD and related complications is highly variable among individuals and is determined by environmental and genetic factors. Genome-wide association studies have uncovered robust and reproducible associations between variations in genes such as PNPLA3, TM6SF2, MBOAT7, GCKR, HSD17B13 and the natural history of NAFLD. These findings have provided compelling new insights into the biology of NAFLD and highlighted potentially attractive pharmaceutical targets. More recently the development of polygenic risk scores, which have shown promising results for the clinical risk prediction of other complex traits (such as cardiovascular disease and breast cancer), have provided new impetus for the clinical validation of genetic variants in NAFLD risk stratification. Herein, we review current knowledge on the genetic architecture of NAFLD, including gene-environment interactions, and discuss the implications for disease pathobiology, drug discovery and risk prediction. We particularly focus on the potential clinical translation of recent genetic advances, d...Continue Reading

Citations

Apr 18, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Yasser FouadDina Attia
Jun 28, 2020·Alimentary Pharmacology & Therapeutics·Jee-Fu Huang, Wan-Long Chuang
Jul 29, 2020·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Jie TanYongning Xin
Sep 16, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Cristiana BiancoLuca Valenti
Oct 8, 2020·World Journal of Gastroenterology : WJG·Anna Di SessaEmanuele Miraglia Del Giudice
Jan 19, 2021·Metabolomics : Official Journal of the Metabolomic Society·Mario MasaroneMarcello Persico
Feb 9, 2021·Hepatology Communications·Joana Vieira Barbosa, Michelle Lai
Feb 12, 2021·Nature Reviews. Gastroenterology & Hepatology·Raj VuppalanchiArun J Sanyal
Feb 13, 2021·Journal of Clinical Medicine·Amedeo Lonardo
Mar 4, 2021·Journal of Hepatology·Alain Dessein
Apr 4, 2021·Journal of Clinical Medicine·Raluca Pais, Thomas Maurel
Apr 4, 2021·Metabolites·Angelo ArmandiElisabetta Bugianesi
Apr 9, 2021·Advances in Therapy·Amedeo LonardoMarco Arrese
Apr 15, 2021·Expert Review of Gastroenterology & Hepatology·Anna Di SessaPierluigi Marzuillo
Apr 24, 2021·Journal of Hepatology·Taekyeong YooUNKNOWN Innovative Target Exploration of NAFLD (ITEN) consortium
Aug 28, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tae-Hwi Schwantes-AnUNKNOWN GenomALC Consortium
May 1, 2021·International Journal of Molecular Sciences·Yoshitaka SakuraiTakashi Kadowaki
May 8, 2021·The Lancet. Gastroenterology & Hepatology·Giovanni TargherChristopher D Byrne
May 15, 2021·Cell·Rohit LoombaGerald I Shulman
May 16, 2021·Seminars in Liver Disease·Søren MøllerLise Lotte Gluud
May 19, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Alessandro Mantovani, Luca Valenti
Feb 28, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elizabeth P NewberryNicholas O Davidson
May 28, 2021·Frontiers in Endocrinology·Somaya Albhaisi, Arun J Sanyal
May 25, 2021·JHEP Reports : Innovation in Hepatology·Cristiana BiancoLuca Valenti
Jun 3, 2021·International Journal of Environmental Research and Public Health·Oriol JuanolaIsabel Gómez-Hurtado
Jun 18, 2021·ESMO Open·R PaternostroM Pinter
Jun 23, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Angelo Armandi, Elisabetta Bugianesi
Jul 24, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luca ValentiMassimo Colombo
Jul 22, 2021·Seminars in Liver Disease·Sabine KahlMichael Roden
Jul 8, 2021·Seminars in Liver Disease·Marco ArreseAriel E Feldstein
Jul 17, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Stefania GrimaudoSalvatore Petta
Aug 14, 2021·Journal of Lipid Research·Olga VvedenskayaAndrej Shevchenko
Aug 22, 2021·Nature Reviews. Endocrinology·Philippe Lefebvre, Bart Staels
Sep 13, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Oscar DanielssonFredrik Åberg
Jul 8, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sílvia VilarinhoRohit Loomba
Jul 22, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Samantha G TilsonLudovic Vallier

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