PMID: 2492267Jan 1, 1989Paper

Update on nitroglycerin use

Heart & Lung : the Journal of Critical Care
P Andrien, L Lemberg

Abstract

Tolerance to nitrates occurs when this class of drugs is administered in a continuous around-the-clock regimen. Nitrate-free intervals from 10 to 12 hours are recommended to prevent nitrate tolerance. Full response with renewed administration occurs with interrupted nitrate therapy.

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