Update on noninfectious uveitis in children and its treatment.

Current Opinion in Rheumatology
Ilaria MaccoraAthimalaipet V Ramanan

Abstract

To give an overview of recently published articles covering risk factors, novel biomarkers and treatment for noninfectious uveitis in children. In the last few years, several genetic markers, serum biomarkers, aqueous humor markers, tear biomarkers and clinical factors have been identified, which are associated with childhood noninfectious uveitis. We describe the most important reports in this field that may help to tailor the screening and monitoring of this population in the future and might become the target of novel therapies. The advances in the biologic therapy of paediatric uveitis, thanks to evidence provided by the SYCAMORE, ADJUVITE and APTITUDE trials, offer new possibilities for the treatment of patients who fail methotrexate with adalimumab and tocilizumab. We discuss the importance of comprehensive outcome measures as proposed by the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC). Paediatric noninfectious uveitis is a sight-threatening condition and the identification of risk factors and novel biomarkers is critical for tailored management. Biologic therapies are revolutionizing the outcomes of patients resistant to conventional therapy. Increasing our knowledge of disease pathoge...Continue Reading

References

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Apr 30, 2019·Health Technology Assessment : HTA·Athimalaipet V RamananMichael W Beresford
Dec 13, 2019·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ethan S Sen, A V Ramanan
Jan 4, 2020·Clinical Rheumatology·Elisabetta MiserocchiRolando Cimaz

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Citations

Mar 9, 2021·Therapeutic Advances in Ophthalmology·Judy L ChenEdmund Tsui
Jul 14, 2021·Investigative Ophthalmology & Visual Science·Roos A W WenninkJonas J W Kuiper
Sep 18, 2021·Acta Ophthalmologica·Carlyn V KouwenbergJoke H de Boer

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