Update on novel endoscopic therapies to treat gastroesophageal reflux disease: A review

World Journal of Gastrointestinal Endoscopy
Jessica HopkinsShahzeer Karmali

Abstract

Endoscopic treatments for gastroesophageal reflux disease (GERD) have become increasingly popular in recent years. While surgical intervention with the Laparoscopic Nissen Fundoplication remains the gold standard, two endoscopic interventions, specifically, are gaining traction in clinical use (EsophyX and Stretta). The EsophyX (EndoGastric Solutions, Inc., Redmond, WA, United States) was developed as a method of restoring the valve at the GE junction through an endoluminal fundoplication (ELF) technique. Long-term data suggests that transoral incisional fundoplication (TIF) with EsophyX may be effective for symptom control and proton pump inhibitor reduction or cessation for up to 2-6 years. There is no evidence that EsophyX is more effective than surgical intervention. TIF may be most effective for patients with HH < 2 cm and Hill Grade I/II valves. Stretta (Mederi Therapeutics, Greenwich, CT, United States) was approved by the Food and Drug Administration in 2000. It delivers radiofrequency energy to the lower esophageal sphincter and gastric cardia. Published reviews of the literature are conflicted in their recommendations of Stretta in the management of GERD. The literature suggests that the Stretta procedure has an accep...Continue Reading

Citations

Oct 7, 2017·Abdominal Radiology·Chandana LallKenneth J Chang
Nov 1, 2016·Digestive Diseases and Sciences·Tony S BrarDennis Yang
Jun 6, 2020·Therapeutic Advances in Gastroenterology·Glenn M Ihde
Sep 3, 2020·Annals of the New York Academy of Sciences·Samuel P BantingHiroshi Mashimo
Nov 8, 2017·Digestive Diseases and Sciences·Yu-Min KungYao-Kuang Wang
Sep 1, 2018·Surgical Endoscopy·Munyaradzi ChimukangaraKyle A Perry
Apr 14, 2021·Esophagus : Official Journal of the Japan Esophageal Society·Madhusudhan R SanakaSiva Raja

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