Update on Renin-Angiotensin-aldosterone blockade in heart failure.

Current Treatment Options in Cardiovascular Medicine
Young-Sin Kim, Barry Greenberg

Abstract

There is convincing evidence that the renin-angiotensin-aldosterone system (RAAS) plays an important role in heart failure (HF), from the events that result in its inception through advanced disease. In particular, RAAS activation is one of the major pathways involved in maladaptive cardiac remodeling, a process that results in progressive cardiac dysfunction. Not surprisingly, strategies targeting the RAAS have substantial benefits in HF. These therapies, which include angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and aldosterone receptor antagonists, have emerged as cornerstones of HF therapy, particularly in patients with systolic dysfunction. Their role in HF with preserved ejection fraction, however, is less certain. New information and approaches targeting RAAS activation continue to emerge. Direct renin inhibitors are hypothesized to have beneficial effects in HF, but further studies are needed to evaluate their efficacy.

References

Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Jan 21, 1993·The American Journal of Cardiology·U Dahlström, E Karlsson
Jul 11, 2002·Journal of the American College of Cardiology·Mariantonietta CicoiraPiero Zardini
Jan 22, 2003·Journal of the American College of Cardiology·Biykem BozkurtA A Knowlton
Apr 2, 2003·The New England Journal of Medicine·Bertram PittUNKNOWN Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators
Nov 12, 2003·The New England Journal of Medicine·Marc A PfefferUNKNOWN Valsartan in Acute Myocardial Infarction Trial Investigators
Aug 6, 2004·The New England Journal of Medicine·David N JuurlinkDonald A Redelmeier
May 11, 2005·American Journal of Hypertension·Roland E Schmieder
Jul 19, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Michikado IwataBarry H Greenberg
Sep 12, 2006·European Heart Journal·John G F ClelandUNKNOWN PEP-CHF Investigators
Nov 13, 2008·The New England Journal of Medicine·Barry M MassieUNKNOWN I-PRESERVE Investigators
May 1, 2008·Circulation. Heart Failure·John J V McMurrayUNKNOWN Aliskiren Observation of Heart Failure Treatment (ALOFT) Investigators

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Citations

Nov 23, 2013·International Journal of Molecular Sciences·Speranza RubattuMassimo Volpe

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