Update on systemic therapy for advanced cutaneous melanoma and recent development of novel drugs

Clinical & Experimental Metastasis
Thein Swe, Kevin B Kim

Abstract

Malignant melanoma is generally chemo- and radio-resistant, and patients with advanced melanoma have a poor prognosis. However, with our increased understanding of the checkpoint immune molecules and genetic alterations of melanoma cells, more effective immunotherapy, such as anti CTLA4 antibody and anti PD-1 antibodies, and targeted drug therapy, such as BRAF inhibitors and MEK inhibitors, have been developed, resulting in improved overall survival and quality of life of patients with advanced melanoma. In addition, emerging technologies to develop prognostic and predictive biomarkers for response to systemic therapy could help clinicians make more accurate assessments of the disease and formulate more effective treatment plans. In this review, current standard systemic therapy options and recently developed novel drugs for advanced melanoma are discussed.

References

Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M KirkwoodR H Blum
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M B AtkinsS A Rosenberg
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P B ChapmanJ M Kirkwood
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Omar EtonRobert S Benjamin
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Oct 31, 2002·Seminars in Oncology·Emilio BajettaDavid Khayat
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John M KirkwoodUNKNOWN Eastern Cooperative Oncology Group
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K M FifeJ F Thompson
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sanjiv S AgarwalaElaine M Rankin
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark E DudleySteven A Rosenberg
Feb 9, 2006·Current Opinion in Immunology·Karl S PeggsJames P Allison
Aug 16, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John A CurtinBoris C Bastian
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer C C HuR Charles Coombes
Dec 17, 2008·Nature·Catherine D Van RaamsdonkBoris C Bastian
Oct 23, 2009·The Journal of Investigative Dermatology·Maria C Garrido, Boris C Bastian
Nov 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Caroline M EmeryLevi A Garraway
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael A CurranJames P Allison
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Sep 8, 2010·The New England Journal of Medicine·Keith T FlahertyPaul B Chapman
Oct 21, 2010·Cancer·Michael A DaviesAgop Bedikian
Nov 19, 2010·The New England Journal of Medicine·Catherine D Van RaamsdonkBoris C Bastian
Nov 26, 2010·Nature·Cory M JohannessenLevi A Garraway
Feb 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Georgina V LongRichard F Kefford
May 28, 2011·Pigment Cell & Melanoma Research·Bianca DevittGrant McArthur
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanUNKNOWN BRIM-3 Study Group
Jun 7, 2011·JAMA : the Journal of the American Medical Association·Richard D CarvajalGary K Schwartz
Jun 22, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jun GuoShukui Qin
Mar 30, 2012·The Lancet Oncology·Kim MargolinF Stephen Hodi
Jun 6, 2012·The New England Journal of Medicine·Keith T FlahertyUNKNOWN METRIC Study Group
Jul 24, 2012·Cell·Eran HodisLynda Chin
Oct 4, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laszlo G RadvanyiPatrick Hwu
Oct 30, 2012·Trends in Immunology·David H Munn, Andrew L Mellor
Dec 4, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chengwen LiuPatrick Hwu
Dec 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin B KimKarl D Lewis
Apr 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kerstin TrunzerAntoni Ribas

❮ Previous
Next ❯

Citations

Oct 28, 2018·Journal of Cancer Research and Clinical Oncology·Miroslawa CichorekKrystyna Dzierzbicka
Jul 12, 2018·Clinical & Experimental Metastasis·Stanley P LeongCarlo Maley
Oct 24, 2019·Current Topics in Medicinal Chemistry·Congcong ZhuQuangang Zhu
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Miroslawa CichorekIwona Pelikant-Malecka

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
dissection
blood
biopsy

Clinical Trials Mentioned

NCT01227889
NCT01721746
NCT01502696
NCT01274338
NCT02506153
NCT03068455
NCT02752074
NCT02263508
NCT02339571
NCT02905266

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

American Journal of Clinical Dermatology
Elisa A RozemanChristian U Blank
Internal Medicine Journal
Victoria Atkinson
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Alexander M Menzies, Georgina V Long
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
R GutzmerFür Komitee Kutane Nebenwirkungen Ado der das Ado
© 2022 Meta ULC. All rights reserved