Update on thalassemia: clinical care and complications

Hematology/oncology Clinics of North America
Melody J Cunningham

Abstract

beta-Thalassemia, originally named Cooley anemia, is an inherited blood disease. Various types of thalassemia are inherited anemias caused by mutations at the globin gene loci on chromosomes 16 and 11, affecting the production of alpha- or beta-globin protein, respectively. The combination of early diagnosis, improvements in monitoring for organ complications, and advances in supportive care have enabled many patients who have severe thalassemia syndromes to live productive, active lives well into adulthood.

References

Apr 1, 1991·The Journal of Pediatrics·K H EhlersM W Hilgartner
Feb 15, 1990·The New England Journal of Medicine·G LucarelliF Albertini
Jun 7, 1990·The New England Journal of Medicine·E P VichinskyB Lubin
Oct 1, 1989·American Journal of Hematology·A EldorA D Heyns
Jan 5, 1967·The New England Journal of Medicine·Y W KanL Lowenstein
Dec 1, 1984·Archives of Disease in Childhood·G A MoroniG Masera
Apr 29, 1998·Acta Haematologica·C Borgna PignattiS Musumeci
Jul 27, 1999·Proceedings of the Association of American Physicians·J B Clegg, D J Weatherall
Sep 12, 2001·Genetic Testing·F LoreyD H Chui
Sep 26, 2001·Bone Marrow Transplantation·G LucarelliE Angelucci
Jan 5, 2002·Blood·Amiram Eldor, Eliezer A Rachmilewitz
Sep 11, 2002·Transfusion Medicine·J-P AllainS Sauleda
Feb 13, 2003·Current Opinion in Hematology·Christopher D Reiter, Mark T Gladwin
Mar 5, 1960·Nature·L E LIE-INJO, B H JO
Dec 17, 2003·British Journal of Haematology·Caterina Borgna-PignattiMaria Grazia Bisconte
Feb 28, 2004·Blood·Melody J CunninghamUNKNOWN Thalassemia Clinical Research Network
Jul 27, 2005·British Journal of Haematology·Roberto F MachadoMark T Gladwin
Oct 13, 2005·Pediatric Blood & Cancer·Susan L KearneyMelody J Cunningham
Nov 18, 2005·Pediatrics·Elliott P VichinskyNancy F Olivieri
Dec 13, 2005·Annals of the New York Academy of Sciences·Elliott P Vichinsky
Dec 13, 2005·Annals of the New York Academy of Sciences·C Borgna-PignattiA Cnaan
Dec 13, 2005·Annals of the New York Academy of Sciences·Mark C WaltersBert Lubin
Dec 13, 2005·Annals of the New York Academy of Sciences·Ellen ButenskyPaul Harmatz
Jul 4, 2006·Blood Cells, Molecules & Diseases·Tamon NishinoDavid W Emery
Aug 1, 2007·Pediatric Transplantation·Mark C Walters
Aug 1, 2007·Pediatric Transplantation·Tom V AdamkiewiczAndrew M Yeager
Aug 4, 2007·American Journal of Hematology·Suradej HongengSurapol Issaragisil
Nov 21, 2007·Hematology·Maria Domenica Cappellini

❮ Previous
Next ❯

Citations

Mar 15, 2012·Expert Opinion on Biological Therapy·Roberto Gambari
Feb 9, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Ghasem Miri-AliabadMajid Naderi
Feb 18, 2012·International Journal of Laboratory Hematology·M SivalingamR Jamal
Mar 25, 2016·Asian Journal of Transfusion Science·Kambiz Davari, Mohammad Soleiman Soltanpour
Nov 23, 2013·Journal of Korean Medical Science·Che Ry HongHyo Seop Ahn
Apr 6, 2012·Expert Review of Hematology·Constance GuillaudMarc Michel
Aug 2, 2019·Journal of Pediatric Hematology/oncology·Taylor RadkeLisa Feuchtbaum
Nov 7, 2012·Journal of Pediatric Hematology/oncology·Anthony N Audino, Nicholas D Yeager
Jun 21, 2013·Expert Review of Hematology·Laura BredaRoberto Gambari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.