PMID: 8962645Mar 1, 1996Paper

Update on the Center for Recombinant Gamete Contraceptive Vaccinogens

American Journal of Reproductive Immunology : AJRI
J C Herr

Abstract

The overall goal of the Center for Recombinant Gamete Contraceptive Vaccinogens is to develop a contraceptive vaccine which will induce antibodies in the female reproductive tract at sufficient levels to block fertilization. It is envisioned that antibodies developed by this vaccine will act to agglutinate, immobilize or coat either the egg or the sperm in the oviduct, uterus, cervix or vagina. Thus, the vaccine will exert its effects before the fertilization event, as a "prefertilization contraceptive." The Center has focused its activities over the past 4 years on four areas: 1) sperm antigens: the identification and characterization of novel sperm surface molecules which are attractive candidates for inclusion in a vaccine; 2) zona antigens: the identification of synthetic peptides derived from the zona pellucida which possess contraceptive potential without adverse pathology; 3) oral vaccine delivery: the development of live Salmonella vectors which deliver vaccine antigens through the oral route and which will stimulate secretory immunity in the female reproductive tract; and 4) animal testing: the testing of vaccine formulations in in vitro fertilization models, in small animals, in monkeys and in baboons. In addition, pr...Continue Reading

References

May 1, 1992·Biology of Reproduction·J A Foster, J C Herr
Apr 1, 1990·Biology of Reproduction·R M WrightJ C Herr
Feb 1, 1990·Biology of Reproduction·J C HerrC J Flickinger
Nov 1, 1986·Biology of Reproduction·J A Shelton, E Goldberg
Aug 1, 1974·Biology of Reproduction·J E Lerum, E Goldberg
May 1, 1974·The Journal of Experimental Medicine·P B Carter, F M Collins
Mar 1, 1984·Biology of Reproduction·J G Alvarez, B T Storey
May 1, 1983·Geriatric Nursing·P K Yen
Feb 1, 1981·Fertility and Sterility·E GoldbergV C Stevens
Jan 1, 1994·Reproduction, Fertility, and Development·M G O'Rand, E E Widgren
Jun 1, 1993·Biology of Reproduction·L A CookerE Goldberg

❮ Previous
Next ❯

Citations

Sep 16, 1999·Journal of Biotechnology·M P BradleyP Bird
Apr 25, 2003·International Journal of Pharmaceutics·P FuentesP Martínez
Jan 1, 1997·American Journal of Reproductive Immunology : AJRI·A B Diekman, J C Herr
Feb 1, 1997·American Journal of Reproductive Immunology : AJRI·C B Coulam
Oct 30, 2012·Ontogenez·I N RozhkovaS Ia Amstislavskiĭ
Feb 14, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P FuentesP Martínez
Mar 21, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Bharati G KhobarekarAtmaram H Bandivdekar
Aug 1, 2007·Proteomics. Clinical Applications·Mark W Duncan, Heather S Thompson
Jan 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jian-Jun ChangLi Xu
Jul 17, 2004·Endocrinology·Moira K O'BryanMark P Hedger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.