Update on the diagnosis and management of Parkinson's disease

Clinical Medicine : Journal of the Royal College of Physicians of London
Christopher Kobylecki

Abstract

Parkinson's disease (PD) is diagnosed where bradykinesia occurs together with rigidity or tremor, in the presence of supporting features. The diagnosis is clinical, and attention should be paid to exclusion criteria indicating an alternative diagnosis and to 'red flag' features. There is no cure or disease-modifying treatment for PD, and the rate of progression is variable. The most effective symptomatic treatment remains levodopa, which has superior benefits for quality of life in early PD compared to other therapies. Motor fluctuations and dyskinesia later in the disease course can be improved with adjunctive treatments. Around 10% of patients per year with refractory motor fluctuations may be eligible for advanced therapies, including deep-brain stimulation surgery. There is emerging evidence for the management of non-motor symptoms in PD, and the importance of multidisciplinary care. In this article, the evidence base for optimal diagnosis and management of PD is discussed.

References

Feb 1, 1993·Archives of Neurology·A J HughesA J Lees
Jun 9, 1998·Journal of Neurology·D G MacMahon, S Thomas
Mar 1, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Mariese A HelyJohn G L Morris
May 12, 2010·Archives of Neurology·Daniel WeintraubAnthony E Lang
Aug 10, 2011·Archives of Neurology·Anna CastriotoElena Moro
Apr 11, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Luke A MasseyHans R Jäger
Feb 15, 2013·The New England Journal of Medicine·W M M SchuepbachUNKNOWN EARLYSTIM Study Group
Jul 19, 2014·Brain : a Journal of Neurology·Roberto CiliaGianni Pezzoli
Jul 22, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Rupam BorgohainUNKNOWN Study 018 Investigators
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaGünther Deuschl
Feb 20, 2018·Parkinsonism & Related Disorders·Kelvin L ChouFabrizio Stocchi
Mar 24, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Susan H FoxUNKNOWN Movement Disorder Society Evidence-Based Medicine Committee
Jun 22, 2018·Neurology·Jean-Christophe CorvolUNKNOWN DIGPD Study Group
Dec 26, 2018·Journal of Parkinson's Disease·E Ray DorseyBastiaan R Bloem
Jan 15, 2019·JAMA Neurology·Eduardo De Pablo-FernándezThomas T Warner
Jan 18, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Klaus SeppiUNKNOWN the collaborators of the Parkinson's Disease Update on Non-Motor Symptoms Study Group on behalf of the Movement Disorders So
Jan 24, 2019·The New England Journal of Medicine·Constant V M VerschuurUNKNOWN LEAP Study Group
Mar 17, 2020·Lancet Neurology·Rob M A de BieAnthony E Lang

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