Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet

Diabetes & Metabolism Journal
Vincenza Spallone

Abstract

The burden of diabetic cardiovascular autonomic neuropathy (CAN) is expected to increase due to the diabetes epidemic and its early and widespread appearance. CAN has a definite prognostic role for mortality and cardiovascular morbidity. Putative mechanisms for this are tachycardia, QT interval prolongation, orthostatic hypotension, reverse dipping, and impaired heart rate variability, while emerging mechanisms like inflammation support the pervasiveness of autonomic dysfunction. Efforts to overcome CAN under-diagnosis are on the table: by promoting screening for symptoms and signs; by simplifying cardiovascular reflex tests; and by selecting the candidates for screening. CAN assessment allows for treatment of its manifestations, cardiovascular risk stratification, and tailoring therapeutic targets. Risk factors for CAN are mainly glycaemic control in type 1 diabetes mellitus (T1DM) and, in addition, hypertension, dyslipidaemia, and obesity in type 2 diabetes mellitus (T2DM), while preliminary data regard glycaemic variability, vitamin B12 and D changes, oxidative stress, inflammation, and genetic biomarkers. Glycaemic control prevents CAN in T1DM, whereas multifactorial intervention might be effective in T2DM. Lifestyle interv...Continue Reading

References

Apr 28, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·B L JohanssonJ Wahren
Aug 3, 2000·The American Journal of Cardiology·J P SinghD Levy
Aug 5, 2000·Journal of Diabetes and Its Complications·O May, H Arildsen
Jun 28, 2003·Diabetes·Antti LoimaalaIlkka Vuori
Jul 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·A ForsénG Sundkvist
Oct 23, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·V SpalloneG Menzinger
Mar 1, 2005·Diabetes Care·Emily B SchroederUNKNOWN Atherosclerosis Risk in Communities (ARIC) study
Mar 29, 2006·Diabetes Care·Mercedes R CarnethonUNKNOWN Diabetes Prevention Program Research Group
Jan 24, 2007·Circulation·Aaron I Vinik, Dan Ziegler
Apr 1, 2008·Diabetes Care·Sabita S Soedamah-MuthuUNKNOWN EURODIAB Prospective Complications Study Group
Jul 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Adil E BharuchaPhillip A Low
Feb 10, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Vincenza SpalloneMaria Rosaria Maiello
Apr 3, 2009·Diabetologia·M Rosengård-BärlundUNKNOWN FinnDiane Study Group
Apr 16, 2009·JAMA : the Journal of the American Medical Association·Lawrence H YoungUNKNOWN DIAD Investigators
Jul 4, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·V SpalloneM R Maiello
Aug 22, 2009·The Journal of Clinical Hypertension·Santiago Tofé Povedano, Bernardo García De La Villa
Sep 2, 2009·Autonomic Neuroscience : Basic & Clinical·I AlamJ N Baxter
Dec 4, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gerald F DiBona, Murray Esler
Mar 11, 2010·Diabetes Care·Caroline A AbbottAndrew J M Boulton
Jul 10, 2010·Journal of the American Society of Nephrology : JASN·Daniel J BrotmanJosef Coresh
Sep 30, 2010·Diabetes Care·Solomon TesfayeUNKNOWN Toronto Diabetic Neuropathy Expert Group
Nov 17, 2010·Hypertension·Tine W HansenJan A Staessen
Jan 8, 2011·Journal of Applied Physiology·Nicholas SjobergDavid A Saint

❮ Previous
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Citations

Jul 31, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·F M M BaeresK Brown-Frandsen
Sep 26, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Scott M WilliamsJohn P H Wilding
Jul 13, 2019·Current Pharmaceutical Design·Niki KatsikiDimitri P Mikhailidis
May 10, 2020·International Journal of Environmental Research and Public Health·Mozania Reis de MatosMaria Lucia Correa-Giannella
Oct 18, 2020·Journal of Clinical Medicine·Angelika Baranowska-JurkunElżbieta Bandurska-Stankiewicz
Nov 10, 2020·Diabetologia·Aikaterini EleftheriadouUazman Alam
Nov 11, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·Ernesto MaddaloniRaffaella Buzzetti
Dec 4, 2020·Birth Defects Research·Sarah D Schlatterer, Adre J du Plessis
Dec 15, 2020·Chronobiology International·Sutanu Dutta ChowdhuryLakshmi Kanta Mondal
Jul 30, 2020·Current Opinion in Pharmacology·Liliana Espinoza, Carie R Boychuk
Jan 19, 2021·Journal of Diabetes Investigation·Yingshan LiuLingling Xu
Mar 19, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Olawale Mathias AkinladeOlufemi Ayodele Soladoye
Apr 4, 2021·Journal of Clinical Medicine·Ditte S KornumKlaus Krogh
Apr 4, 2021·Journal of Personalized Medicine·Mar Sempere-BigorraOmar Cauli
Apr 24, 2021·World Journal of Diabetes·Jake RajbhandariJoseph M Pappachan
May 30, 2021·Nature Reviews. Endocrinology·Gordon SloanSolomon Tesfaye
Jun 26, 2021·World Journal of Diabetes·Alice DuqueLuiz Fernando Rodrigues
Jul 27, 2021·Hormones : International Journal of Endocrinology and Metabolism·Marieta P TheodorakopoulouKonstantina Dipla
Aug 20, 2021·Metabolism: Clinical and Experimental·Simona Cernea, Itamar Raz
Aug 28, 2021·Current Diabetes Reports·I H TeohJ D Schofield
Aug 26, 2021·Journal of Diabetes and Its Complications·Vinni Faber RasmussenAstrid Juhl Terkelsen
Sep 8, 2021·Scandinavian Journal of Gastroenterology·Dag André SangnesEirik Søfteland
Oct 3, 2021·BMJ Open Diabetes Research & Care·Marie Mathilde Bjerg ChristensenMarit Eika Jørgensen
Dec 11, 2021·Acta Cardiologica·Hellen Da SilvaPatrick Calders

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

Sudoscan

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