PMID: 489857Nov 1, 1979Paper

Update on the male and female climateric

Journal of the American Geriatrics Society
R B GreenblattP K Natrajan

Abstract

The gonadal steroids--estrogens and androgens--appear to have a mood-elevating, psychotonic effect. The improved sense of well-being and increased vigor probably is engendered by restoration of somatic efficiency and psychic equilibrium. 1. The male climacteric, as observed in a limited number of men, is associated with a low level of serum testosterone. The levels of follicle-stimulating hormone and luteinizing hormone are not elevated because estrogen concentration continues unaltered well into old age. Androgen replacement therapy often lessens fatigue, depression and headaches, and headaches, and improves libidinous drives. 2. In the aging female, many climatric symptoms other than those due to vasomotor instability were heretofore considered merely coincidental. Recent studies suggest that the metabolism of cerebral hormones is markedly influenced by endogenous and exogenous gonadal steroids. Thus, postmenopausal depression, headaches, and nervousness may be hormone-dependent symptoms. 3. The incidence of endometrial cancer is no greater and is probably less in estrogen-treated women than in women not treated with estrogen, if regular cyclic courses of an oral progestogen are added to the regimen.

References

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Citations

Nov 12, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Maria AndrikoulaGordana Prelevic
Aug 1, 1982·Pathology, Research and Practice·R B GreenblattL D Stoddard
Oct 22, 2003·Clinics in Geriatric Medicine·John E Morley
Jun 22, 2012·International Journal of Endocrinology·Mario AmoreMaurizio Pompili
Jan 31, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alvin M Matsumoto
Nov 1, 1982·Clinics in Endocrinology and Metabolism·J M DavidsonW J Greenleaf
Aug 30, 1980·British Medical Journal
Feb 20, 2009·Aging Clinical and Experimental Research·Mario AmorePietro Tagariello
Jan 12, 2020·Hormone Molecular Biology and Clinical Investigation·Donald Pfaff, Farid Saad
Jan 25, 2012·Journal of Homosexuality·Saskia AertsJohn Vincke

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