Update on the Mechanisms of Pulmonary Inflammation and Oxidative Imbalance Induced by Exercise

Oxidative Medicine and Cellular Longevity
O F AranedaM Tuesta

Abstract

The mechanisms involved in the generation of oxidative damage and lung inflammation induced by physical exercise are described. Changes in lung function induced by exercise involve cooling of the airways, fluid evaporation of the epithelial surface, increased contact with polluting substances, and activation of the local and systemic inflammatory response. The present work includes evidence obtained from the different types of exercise in terms of duration and intensity, the effect of both acute performance and chronic performance, and the influence of special conditions such as cold weather, high altitude, and polluted environments. Levels of prooxidants, antioxidants, oxidative damage to biomolecules, and cellularity, as well as levels of soluble mediators of the inflammatory response and its effects on tissues, are described in samples of lung origin. These samples include tissue homogenates, induced sputum, bronchoalveolar lavage fluid, biopsies, and exhaled breath condensate obtained in experimental protocols conducted on animal and human models. Finally, the need to simultaneously explore the oxidative/inflammatory parameters to establish the interrelation between them is highlighted.

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Citations

Apr 22, 2016·Journal of Physiology and Biochemistry·M TuestaO F Araneda
Aug 16, 2016·Mediators of Inflammation·KarryAnne K BelangerLeopoldo Aguilera-Aguirre
Aug 11, 2020·European Journal of Applied Physiology·Felipe Contreras-BriceñoOscar F Araneda
Mar 27, 2019·Oxidative Medicine and Cellular Longevity·Ana Paula SierraRodolfo Paula Vieira
Feb 8, 2021·Medical Hypotheses·Lucio Della Guardia, Roberto Codella
Dec 9, 2020·International Journal of Environmental Research and Public Health·Krzysztof KocotMałgorzata Kowalska
Mar 7, 2021·European Journal of Applied Physiology·Denisse Valladares-IdeLuis Peñailillo

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Methods Mentioned

BETA
BALF
bronchoalveolar
lavage
biopsy
MDA
bronchoalveolar lavage
biopsies

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