Update on the Pharmacological Treatment of Tics with Dopamine-Modulating Agents

ACS Chemical Neuroscience
Sabine MogwitzVeit Roessner

Abstract

More than 40 years of research and clinical practice have proven the effectiveness of dopamine receptor antagonists in the pharmacological treatment of tics. A blockade of the striatal dopamine-D2 receptors is mainly responsible for their tic-reducing effect. A broad spectrum of dopamine-modulating agents, such as typical and atypical antipsychotics, but also dopamine receptor agonists are used with an immanent discord between experts about which of them should be considered as first choice. The present Review outlines the state of the art on pharmacological treatment of tics with dopamine-modulating agents by giving an systematic overview of studies on their effectiveness and a critical discussion of their specific adverse effects. It is considered as an update of a previous review of our research group published in 2013. The Review closes with a description of the current resulting treatment recommendations including the results of a first published revised survey on European expert's prescription preferences. Based on the enormously growing evidence on its effectiveness and safety, aripiprazole currently seems to be the most promising agent in the pharmacological treatment of tics. Furthermore, benzamides (especially tiaprid...Continue Reading

Citations

Jul 12, 2019·Expert Review of Neurotherapeutics·Joey Ka-Yee EssoeJoseph F McGuire
Jul 30, 2019·Continuum : Lifelong Learning in Neurology·Harvey S Singer
Apr 3, 2020·Journal of Child Neurology·Himadri PatelAshutosh Kumar
Mar 25, 2021·Neuroscience and Biobehavioral Reviews·Asne SenbergVeit Roessner
Jul 27, 2021·Current Problems in Pediatric and Adolescent Health Care·Kallol K Set, Jacqueline N Warner
Sep 4, 2020·Journal of Child and Adolescent Psychopharmacology·Lotte RasmussenAnton Pottegård
Oct 9, 2021·The International Journal of Neuroscience·Fengqiao SunXiaohua Zhang
Nov 11, 2021·European Child & Adolescent Psychiatry·Veit RoessnerKerstin J Plessen

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