PMID: 11331927May 2, 2001Paper

Update on the role of H pylori infection in gastrointestinal disorders

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
Hugh Chaun

Abstract

Infection with Helicobacter pylori is accepted as the primary cause of peptic ulcer disease, and there is evidence to suggest its role in other gastrointestinal disorders. An estimated 20% to 40% of the Canadian population is infected with H pylori; however, clinically relevant disease is present in only approximately 10% to 20% of these individuals. Therefore, it is crucial to identify the diseases for which eradication of H pylori is beneficial to ensure that patients do not receive unnecessary treatment. In patients with ulcers induced by long term treatment with nonsteroidal anti-inflammatory drugs, preliminary results suggest that eradication of H pylori may reduce the risk of peptic ulcer bleeding. Furthermore, a benefit has been observed for the eradication of H pylori before patients commence therapy with a nonsteroidal anti-inflammatory drug. An association between the presence of H pylori and specific dyspeptic symptoms has yet to be established; however, there may be a subset of patients with functional dyspepsia who benefit from the eradication of H pylori. The relationship between gastroesophageal reflux disorder and H pylori infection remains unclear. In Canada, the recommended therapy for the eradication of H pyl...Continue Reading

Citations

Jan 12, 2002·Circulation Research·François MachPierre Michetti
Feb 2, 2002·Applied and Environmental Microbiology·Katherine H BakerDiane S Herson
Jul 14, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·A B SzczepanikJ Windyga
Feb 5, 2021·Frontiers in Cell and Developmental Biology·Bohan LiuQiliang Xiao

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