PMID: 8613495Nov 1, 1995Paper

Update on the use of intravenous immune globulin in the treatment of patients with inflammatory muscle disease

Journal of Clinical Immunology
Marinos C Dalakas

Abstract

The inflammatory myopathies consist of three distinct groups: dermatomyositis, polymyositis, and inclusion body myositis. Dermatomyositis is distinguished by its characteristic rash, while polymyositis is a diagnosis of exclusion. Inclusion body myositis is characterized by early involvement of distal muscle groups and the quadriceps. Definitive diagnosis is made by muscle biopsy, which demonstrates histological features characteristic for each disorder. Immune mechanisms play a role in the pathogenesis of the inflammatory myopathies. A complement-mediated microangiopathy is seen in dermatomyositis, while there is evidence for a T cell-mediated process in polymyositis and inclusion body myositis. Treatment with prednisone is helpful to a majority of patients for a period of time. Immunosuppressive drugs have met with limited success. We describe a group of patients with dermatomyositis, resistant to available therapies, whose muscle strength, skin changes, and muscle biopsies improved significantly during treatment with intravenous immune globulin. The treatment of polymyositis and inclusion body myositis with intravenous immune globulin is currently under study.

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Citations

Aug 11, 2006·Rheumatology International·Sumiyuki MiiKensei Katsuoka
Jul 23, 2009·BMJ : British Medical Journal·Steven A Greenberg
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Marcia Cristina Zago Novaretti, Carla Luana Dinardo
Jul 25, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander EnkDetlef Zillikens
Jan 7, 2015·Nature Reviews. Neurology·Jan D LünemannMarinos C Dalakas
Oct 21, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A H EnkD Zillikens
Dec 31, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander EnkDetlef Zillikens
Feb 19, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander EnkDetlef Zillikens
Nov 1, 2007·Dermatologic Therapy·Anthony P Fernandez, Francisco A Kerdel
May 22, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Eva HadaschikAlexander Enk
Sep 25, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jan D LünemannMarinos C Dalakas
Jul 29, 2000·Seminars in Pediatric Neurology·N F Schor

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