Update on the use of topical NSAIDs for the treatment of soft tissue and musculoskeletal pain: a review of recent data and current treatment options

The Physician and Sportsmedicine
Alan R BrewerCharles E Argoff

Abstract

Topical nonsteroidal anti-inflammatory drugs (NSAIDs) have an emerging role in the treatment of certain types of acute pain. In addition to their convenience, efficacy, and safety, they are an attractive option, particularly when considering current concerns about the safety of traditional NSAIDs and cyclooxygenase-2 (COX-2) inhibitors (coxibs). Topical analgesics act largely within the peripheral nervous system. Studies have demonstrated that topical NSAIDs penetrate the skin and distribute to the target tissues underlying the application site. Because the pharmacologically effective dose is delivered at the site of pain, there is minimal systemic absorption and risk of related adverse events. Topical NSAIDs have been used for many years in Europe, with extensive post-marketing data available for some of the agents. Three topical NSAID formulations have recently been approved for use in the United States: the diclofenac epolamine topical patch 1.3% (DETP), diclofenac sodium 1% gel, and diclofenac sodium topical solution 1.5%. Topical NSAIDs provide a therapeutic option for treatment of acute, localized, soft tissue injuries or painful conditions in areas of the body that can be readily treated using the topical route of admini...Continue Reading

References

Sep 1, 1994·Journal of Accident & Emergency Medicine·J Campbell, T Dunn
Mar 6, 1998·BMJ : British Medical Journal·R A MooreH J McQuay
Apr 5, 2003·Skin Pharmacology and Applied Skin Physiology·J HadgraftP H Rosher
Oct 25, 2003·Toxicology and Applied Pharmacology·Urs A Boelsterli
Jan 20, 2004·Praxis·G GallacchiJ L Heidecker
May 19, 2004·BMC Family Practice·Lorna MasonHenry J McQuay
Nov 9, 2005·Drugs in R&D·Bernard Mazières
Mar 14, 2007·Journal of Pain and Symptom Management·Steven P Stanos
Jun 28, 2007·The Nurse Practitioner·Bill McCarberg, Yvonne D'Arcy
Dec 7, 2007·Anesthesiology Clinics·Gary McCleane
Dec 11, 2008·Clinical Drug Investigation·Birte Petersen, Stefano Rovati
Nov 26, 2009·Seminars in Arthritis and Rheumatism·H Richard BarthelRoy D Altman
Mar 10, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Simon HaroutiunianArthur G Lipman

❮ Previous
Next ❯

Citations

May 24, 2011·Seminars in Oncology·Michael D Stubblefield
Jan 18, 2014·Pain Practice : the Official Journal of World Institute of Pain·Giannapia AffaitatiRaffaele Costantini
May 10, 2016·The American Journal of Emergency Medicine·Mustafa SerinkenYalcin Golcuk
May 29, 2016·The Medical Clinics of North America·Melinda S Loveless, Adrielle L Fry
May 21, 2016·Foot & Ankle International·Mustafa SerinkenHayri Elicabuk
Oct 28, 2011·The Physician and Sportsmedicine·Sanford H Roth, Shane Anderson
May 28, 2016·Journal of Back and Musculoskeletal Rehabilitation·Banu DilekKemal Nas
Mar 12, 2020·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·David P TrofaChristopher S Ahmad
Jun 13, 2017·PM & R : the Journal of Injury, Function, and Rehabilitation·Olga Velasco-RoldánÁngel Oliva-Pascual-Vaca

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Simon HaroutiunianArthur G Lipman
Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Fakhereh Mirrashed, Jonathan C Sharp
Current Opinion in Chemical Biology
R PanchagnulaP Ramarao
© 2021 Meta ULC. All rights reserved