PMID: 11897878Mar 19, 2002Paper

Update on thiol status and supplements in physical exercise

Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée
C K Sen

Abstract

Strenuous physical exercise represents a condition that is often associated with increased production of reactive oxygen species in various tissues. One of the most reliable indices of exercise-induced oxidant production is tissue glutathione oxidation. In humans, exercise-induced blood glutathione oxidation is rapid and subject to control by antioxidant supplementation. The objective of this brief review is to provide an update of our current understanding of cellular thiols and thiol antioxidants. Cellular thiols are critically important in maintaining the cellular antioxidant defense network. In addition, thiols play a key role in regulating redox-sensitive signal transduction process. Lipoic acid is a highly promising thiol antioxidant supplement. Recent studies have clarified that while higher levels of oxidants may indeed inflict oxidative damage, oxidants are not necessarily deleterious. Under certain conditions oxidants may function as cellular messengers that regulate a multitude of signal transduction pathways. In light of this, the significance of oxidants in various aspects of biology needs to be revisited.

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Citations

Oct 17, 2008·Physiological Reviews·Scott K Powers, Malcolm J Jackson
Apr 1, 2006·European Journal of Nutrition·Dario EliaJudit Jakus
May 29, 2012·Free Radical Biology & Medicine·F J Llorente-CantareroJ L Pérez-Navero
Jun 24, 2004·Nutrition·Manfred LamprechtKarl Oettl
Jun 3, 2015·Journal of Tissue Engineering and Regenerative Medicine·Kazushi IkedaMasamichi Kamihira
Jul 24, 2007·Biochemical and Biophysical Research Communications·Isabella SaviniLuciana Avigliano
May 27, 2008·Journal of the International Society of Sports Nutrition·Chad Kerksick, Darryn Willoughby
Jun 17, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Richard J Bloomer, Allen H Goldfarb
Aug 31, 2010·Journal of Strength and Conditioning Research·Hayriye Cakir-AtabekNihat Gündüz

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