Update on tissue renin-angiotensin systems.

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Michael Bader, D Ganten

Abstract

Angiotensin (Ang) II is not only generated in the circulation by renin and angiotensin-converting enzyme (ACE) but also is produced locally in numerous organs including kidney, vessels, heart, adrenal gland, eye, testis, and brain. Furthermore, widely distributed mast cells have been shown to be a production site. Local Ang II production process is commonly termed the result of a "tissue" renin-angiotensin system (RAS). Because pharmacological experiments do not easily allow targeting of specific tissues, many novel findings about the functional importance of tissue RAS have been collected from transgenic rodent models. These animals either overexpress or lack RAS components in specific tissues and thereby elucidate their local functions. The data to date show that in most tissues local RAS amplify the actions of circulating Ang II with important implications for physiology and pathophysiology of cardiovascular diseases. This review summarizes the recent findings on the importance of tissue RAS in the most relevant cardiovascular organs.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G N GillM H Simonian
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D GantenU Ganten
Mar 1, 1990·Molecular Endocrinology·C A JonesK W Gross
Dec 22, 1967·Science·J W Ryan
Jul 2, 1971·Science·D GantenJ Genest
Jul 1, 1974·The American Journal of Physiology·D GantenJ Genest
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M Naruse, T Inagami
Mar 1, 1993·The Journal of Clinical Investigation·O W MoeW L Henrich
Jul 1, 1994·Hypertension·A H DanserM A Schalekamp
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·L HeinV J Dzau
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·M SchinkeM Bader
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·P ParadisM Nemer
Jun 27, 2000·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M Bader, D Ganten
May 19, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M BaderD Ganten
Nov 3, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·S HoffmannH Urata
Feb 5, 2002·Annual Review of Physiology·Taiji MatsusakaIekuni Ichikawa
Jun 1, 2002·Circulation Research·Jörg PetersJohn J Mullins
Jun 5, 2002·The Journal of Clinical Investigation·Genevieve NguyenJean-Daniel Sraer
Jun 20, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ningling KangMichael Bader
Oct 26, 2002·The Journal of Biological Chemistry·Nadheige LochardTimothy L Reudelhuber
Nov 5, 2002·The American Journal of Pathology·Dominik N MullerFriedrich C Luft
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robson A S SantosThomas Walther
Apr 13, 2004·American Journal of Physiology. Renal Physiology·Julie L LavoieCurt D Sigmund
Mar 8, 2005·Current Hypertension Reports·Koji Sakai, Curt D Sigmund
Apr 21, 2005·The Journal of Clinical Investigation·Steven D CrowleyThomas M Coffman

❮ Previous
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Citations

Sep 6, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hsiang-Hao HsuHermann Pavenstädt
Apr 25, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·David FournierMiguel A Andrade-Navarro
Nov 15, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Craig Comiter
Oct 12, 2012·Japanese Journal of Radiology·Nevbahar Akcar DeğirmenciHuseyin Yıldırım
May 16, 2009·Current Hypertension Reports·Brett R Cowan, Alistair A Young
Dec 3, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Luiza A RabeloMichael Bader
Apr 8, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuichiro YamadaKohzo Nagata
Jul 14, 2011·Genetic Testing and Molecular Biomarkers·Sevgi YimeniciogluMehmet Yavuz Coskun
Oct 23, 2010·Journal of Cardiovascular Pharmacology·Mahmoud M El-Mas, Abdel A Abdel-Rahman
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Michael Bader
Jun 8, 2012·American Journal of Physiology. Renal Physiology·Jun ZhangJeffrey D Peterson
Jan 7, 2011·American Journal of Physiology. Renal Physiology·Rifat SabuhiTahir Hussain
Nov 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Jeffrey PettyFrank M Torti
Jul 16, 2010·The Journal of Clinical Investigation·Tobias V LanzLawrence Steinman
Mar 26, 2010·The Journal of Clinical Investigation·Daniela Zablocki, Junichi Sadoshima
Jul 3, 2009·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiroko TanakaYoshifusa Aizawa
Jun 1, 2013·PloS One·Diana HildebrandHartmut Schlüter
Feb 26, 2010·Biological Chemistry·Cibele C CardosoMichael Bader
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric G KrauseRandall R Sakai
Apr 21, 2012·Journal of the American Society of Nephrology : JASN·Taiji MatsusakaIekuni Ichikawa
Aug 8, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Lijuan WangShaojun Wen
Jun 15, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Hye Ryoun JangYoon-Goo Kim
Dec 31, 2014·International Journal of Molecular Sciences·Kaustav Majumder, Jianping Wu
Mar 17, 2009·The Journal of Sexual Medicine·Li-Ming Jin
Jun 27, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Chunguang LiYing Peng
Sep 6, 2012·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jorge F GianiFernando P Dominici
Nov 21, 2014·The Journal of Sexual Medicine·Rodrigo A Fraga-SilvaNikolaos Stergiopulos
Jul 31, 2013·The Journal of Sexual Medicine·Rodrigo A Fraga-SilvaRobson A S Santos
Jul 31, 2013·The Journal of Sexual Medicine·Hicham LabaziR Clinton Webb
Mar 7, 2012·Peptides·Jörg Peters
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Chang-zhen RenYang-kai Wang
Feb 22, 2011·Peptides·Ovidiu C BaltatuMichael Bader
Mar 15, 2011·Peptides·Qianni Cheng, Po Sing Leung
Mar 30, 2010·Regulatory Peptides·Jaspal PatilHans Imboden

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