PMID: 9425574Jan 13, 1998Paper

Update: transmission of HIV-1 from mother to child

Current Opinion in Obstetrics & Gynecology
Mary Glenn Fowler

Abstract

Mother-to-child transmission near the time of birth is the primary route of HIV-1 infection among infants and young children. Throughout the world, 1000 babies a day become infected with HIV, and cumulative global estimates are that 3 million children have been infected since the HIV pandemic began. Although major advances have been made in reducing mother-to-child transmission of HIV-1 in the USA and Europe through the use of an intensive regimen of zidovudine, many research questions remain unresolved. These include (1) viral and host characteristics which hinder or facilitate perinatal HIV transmission (i.e. the role played by viral load, the placenta and obstetric risk factors); (2) the proportion of transmission occurring in utero, intrapartum or during the breast feeding period; and (3) the mode of action of the successful zidovudine regimen. Studies published within the past year have shed light on several of these research topics. In 1996-1997 a number of important studies were published which support a general correlation between maternal viral load and infant HIV infection. The most recent studies do not, however, support the theory that there is a threshold below which transmission cannot occur, and also indicate tha...Continue Reading

Citations

Jul 3, 2007·SAHARA J : Journal of Social Aspects of HIV/AIDS Research Alliance·K N MukoE N Shu
Oct 13, 2006·Current Opinion in Infectious Diseases·G Tudor-Williams, E G Lyall
Aug 10, 2001·Infectious Diseases in Obstetrics and Gynecology·B N LeeJ M Reuben
Jan 17, 2002·Acta Microbiologica Et Immunologica Hungarica·C Casper, E M Fenyö
Dec 15, 2012·Human Immunology·Ma LuoFrancis A Plummer

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