Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV

The Journal of General Virology
Orlando de JesusPaul J Farrell

Abstract

Two sequences required for activity of the Epstein-Barr virus BART RNA promoter in transfection assays have been identified by site-directed mutagenesis. One contains a consensus AP-1 site; the other has some similarity to Ets and Stat consensus binding sites. Candidate sequences were suggested by mapping a region of unmethylated DNA in EBV around the BART promoter followed by in vivo footprinting the promoter in the C666-1 nasopharyngeal carcinoma cell line, which expresses BART RNAs. The data are presented in the context of a revised EBV DNA sequence, known as EBV wt, that is proposed as a future standard sequence for EBV.

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L KarranB E Griffin
Dec 1, 1991·Journal of Virology·N Raab-TraubA P Lanier
Oct 15, 1988·International Journal of Cancer. Journal International Du Cancer·P BussonT Tursz
Feb 1, 1995·Journal of Virology·R H Sadler, N Raab-Traub
Feb 21, 1998·Nucleic Acids Research·T HeinemeyerN A Kolchanov
Aug 17, 1999·International Journal of Cancer. Journal International Du Cancer·S T CheungJ C Lee
Mar 9, 2000·Journal of Virology·P R SmithP J Farrell
Dec 19, 2000·Journal of Virology·S Kusano, N Raab-Traub

❮ Previous
Next ❯

Citations

May 16, 2008·Journal of Virology·Walter LucchesiPaul J Farrell
Jul 11, 2008·Journal of Virology·Rachel Hood EdwardsNancy Raab-Traub
Jan 23, 2009·Journal of Virology·Brandon W HensonPrashant Desai
Nov 27, 2004·Journal of Virology·Wolfgang AmonPaul J Farrell
Jan 15, 2005·Journal of Virology·Honglin ChenS Diane Hayward
Feb 14, 2006·Journal of Virology·Jing YuanElliott Kieff
Nov 12, 2010·Immunome Research·Johannes SöllnerBernd Mayer
Jan 1, 2009·Mediterranean Journal of Hematology and Infectious Diseases·Maria TakacsJanos Minarovits
Apr 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael A CalderwoodEric Johannsen
Nov 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Eric JohannsenElliott Kieff
Dec 20, 2011·Seminars in Cancer Biology·Aron R Marquitz, Nancy Raab-Traub
Mar 21, 2012·The Journal of Pathology·Angela K-F LoKwok-Wai Lo
Feb 24, 2006·Virus Research·Duncan J McGeochAndrew J Davison
Dec 8, 2005·Veterinary Microbiology·Mathias Ackermann
Jan 15, 2009·The Journal of General Virology·Maha Al-MozainiPaul J Farrell
Apr 17, 2015·Journal of Medical Virology·Marco NevesHugo Sousa
Mar 30, 2010·Veterinary Microbiology·Andrew J Davison
Feb 24, 2006·Virology·Aidan DolanDuncan J McGeoch
Nov 4, 2016·Nature Reviews. Cancer·Lawrence S YoungPaul G Murray
Dec 31, 2016·The Journal of General Virology·Lu ZhouChun-Kui Shao
Jan 1, 2012·Pathogens·Stelios Tzellos, Paul J Farrell
Mar 2, 2016·Viruses·Hin Kwok, Alan Kwok Shing Chiang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.