Updated evidence of the association between toxocariasis and epilepsy: Systematic review and meta-analysis

PLoS Neglected Tropical Diseases
Jaime LunaPierre-Marie Preux

Abstract

To gain further insight on the association between human toxocariasis and epilepsy in light of the new evidence in the last years. A systematic review was conducted without date and language restriction in the following electronic databases: MEDLINE (PubMed), Ingenta Connect, Science Direct (Elsevier), RefDoc, Scopus, HighWire, Scielo and the database of the Institute of Neuroepidemiology and Tropical Neurology of the Limoges University (IENT). Two investigators independently conducted the search up to November 2017. A pooled odds ratio (OR) was estimated using a random effects model. Meta-regression was conducted to investigate potential sources of heterogeneity. Database search produced 204 publications. Eleven case-control studies were included that were carried out in 13 countries worldwide. A total number of 4740 subjects were considered (2159 people with epilepsy and 2581 people without epilepsy). The overall pooled OR was 1.69 (95% CI 1.42-2.01) for the association between epilepsy and Toxocara spp. seropositivity. A positive association was constantly reported in the restricted analysis (WB as confirmatory or diagnostic test, younger population, and population-based studies). Meta-regression showed no statistically sign...Continue Reading

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Citations

Mar 21, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mohammad Reza RezaiemaneshSeyed Hossein Hejazi
Apr 30, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Maryam SadeghiAli Rostami
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May 25, 2021·Veterinary Parasitology : Regional Studies and Reports·Gajendra N BhangaleRavindra S Tayde
Oct 26, 2021·Parasitology·Sara R HealyMartha Betson

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Epi
RefDoc
Info
Stata
Scielo
HighWire
Scopus

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