Updated patterns of failure after multimodality therapy for malignant pleural mesothelioma

The Journal of Thoracic and Cardiovascular Surgery
Elizabeth H BaldiniDavid J Sugarbaker

Abstract

We have previously described patterns of failure after extrapleural pneumonectomy and multimodality therapy for malignant pleural mesothelioma and sought to update our results with a larger cohort of recent patients. A total of 169 patients underwent extrapleural pneumonectomy without preoperative chemotherapy between 2001 and 2010. Data for treatment, recurrence, and survival were determined from medical records. A thoracic radiologist reviewed postoperative computed tomography or positron emission tomography computed tomography scans to determine sites of recurrence. Time to recurrence was estimated by the Kaplan-Meier method. Rates were compared using the Fisher exact test. The median age of patients was 62 years. Histology on final pathology was epithelial for 104 patients (62%) and nonepithelial for 65 patients (38%). A total of 132 patients (78%) received heated intraoperative chemotherapy; 77 patients (45%) received adjuvant chemotherapy, and 71 patients (42%) received adjuvant radiation therapy. Most chemotherapy regimens included platinum or pemetrexed. Median radiation therapy dose was 54 Gy. Among 158 evaluable patients, a recurrence developed in 118 (75%). Median follow-up was 83 months, median time to recurrence wa...Continue Reading

References

Nov 1, 1992·The Annals of Thoracic Surgery·D J SugarbakerG Strauss
Oct 3, 2001·The Journal of Thoracic and Cardiovascular Surgery·V W RuschR J Ginsberg
Dec 18, 2001·Journal of Surgical Oncology·N MerrittJ D Urschel
Feb 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Anesa AhamadKenneth M Forster
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas J VogelzangPaolo Paoletti
Jul 23, 2003·International Journal of Radiation Oncology, Biology, Physics·Santosh YajnikValerie W Rusch
Apr 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William G RichardsDavid J Sugarbaker
Jun 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Aaron M AllenElizabeth H Baldini
Apr 4, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Federico ReaFrancesco Sartori
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·David J Sugarbaker
May 1, 2007·International Journal of Radiation Oncology, Biology, Physics·David C RiceCraig W Stevens
Aug 7, 2007·International Journal of Radiation Oncology, Biology, Physics·Aaron M AllenElizabeth H Baldini
Feb 12, 2008·International Journal of Radiation Oncology, Biology, Physics·Edward F MilesLawrence B Marks
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc de PerrotMichael R Johnston
Apr 15, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Claus Andrup KristensenSvend-Aage Engelholm
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee M KrugNicholas J Vogelzang
May 1, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Vishal GuptaKenneth E Rosenzweig
Aug 25, 2009·The Annals of Thoracic Surgery·Gordon BuduhanEric Vallières
Jun 8, 2010·The European Respiratory Journal·P E Van SchilUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC) Lung Cancer Group
May 31, 2011·The Annals of Thoracic Surgery·Joseph S FriedbergKeith Cengel
Aug 26, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Philippe GiraudMarc-André Mahé
Nov 2, 2011·The Lancet Oncology·Walter WederNico van Zandwijk
Nov 15, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sandro TonoliStefano Maria Magrini
Dec 19, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Daniel R GomezDavid C Rice
Feb 19, 2013·The Journal of Thoracic and Cardiovascular Surgery·Valerie RuschUNKNOWN participants in the 2012 International Mesothelioma Interest Group Congress
Jan 22, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·B C John ChoMarc de Perrot

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Citations

Dec 8, 2015·Future Oncology·Semih Halezeroğlu, Marcello Migliore
Mar 24, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Annabel J SharkeyDavid A Waller
Mar 24, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Pierre MordantMarc de Perrot
Nov 22, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Arthur KostronIsabelle Opitz
Dec 4, 2014·The Journal of Thoracic and Cardiovascular Surgery·Tom Treasure, Fergus Macbeth
Jul 19, 2016·Thoracic Surgery Clinics·Andrea S Wolf, Raja M Flores
Sep 7, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Annabel J SharkeyDavid A Waller
Oct 1, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·David RiceUNKNOWN Mesothelioma Domain of the IASLC Staging and Prognostic Factors Committee, advisory boards and participating institutions
Nov 2, 2019·Expert Review of Respiratory Medicine·Eleonora FaccioliFederico Rea
Jan 19, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hedy L KindlerRaffit Hassan
May 29, 2020·Japanese Journal of Clinical Oncology·Akifumi NakamuraSeiki Hasegawa
Aug 18, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David B NelsonBoris Sepesi
Sep 12, 2020·International Journal of Clinical Oncology·Akifumi NakamuraSeiki Hasegawa
Oct 17, 2017·Annual Review of Medicine·Ori Wald, David J Sugarbaker
Jun 6, 2017·Expert Review of Respiratory Medicine·Giuseppe MarulliFederico Rea
Jun 1, 2018·International Journal of Molecular Sciences·Kathrin OehlMayura Meerang
Nov 14, 2020·Current Opinion in Oncology·Katharina SinnM Alireza Hoda
Feb 2, 2021·Annals of Surgical Oncology·Taylor Kantor, Elliot Wakeam
Feb 21, 2021·Seminars in Thoracic and Cardiovascular Surgery·Akifumi NakamuraSeiki Hasegawa

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