Abstract
Purpose: We evaluated the effect on long-term survival of adding rituximab (R) to BEAM (carmustine, etoposide, cytarabine, and melphalan) conditioning with or without yttrium-90 ibritumomab tiuxetan (90YIT) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) undergoing autologous stem cell transplant (ASCT).Experimental design: Patients were enrolled on three consecutive phase II clinical trials. Patients received two doses of rituximab (375 and 1,000 mg/m2) during mobilization of stem cells, followed by 1,000 mg/m2 on days +1 and +8 after ASCT with R-BEAM or 90YIT-R-BEAM (90YIT dose of 0.4 mCi/kg) conditioning.Results: One hundred thirteen patients were enrolled, with 73 receiving R-BEAM and 40 receiving 90YIT-R-BEAM. All patients had a prior exposure to rituximab. The median follow-up intervals for survivors were 11.8, 8.1, and 4.2 years in the three trials, respectively. The 5-year disease-free survival (DFS) rates were 62% for R-BEAM and 65% for 90YIT-R-BEAM (P = 0.82). The 5-year overall survival rates were 73% and 77%, respectively (P = 0.65). In patients with de novo DLBCL, survival outcomes of the germinal center/activated b-cell histologic subtypes were similar with 5-year OS rates (P = 0.52) and DFS rates ...Continue Reading
References
Nov 28, 1991·The New England Journal of Medicine·J G GribbenG J Freeman
Dec 7, 1995·The New England Journal of Medicine·T PhilipJ L Harousseau
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonG P Canellos
Feb 17, 2000·Nature·A A AlizadehL M Staudt
Apr 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J C ByrdI W Flinn
Apr 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S M O'BrienM J Keating
Jun 20, 2003·Bone Marrow Transplantation·S GalimbertiM Petrini
Aug 2, 2003·Blood·Koen van BesienJulie M Vose
Sep 25, 2003·Blood·Christine P HansWing C Chan
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Issa F KhouriRichard E Champlin
Jul 9, 2005·Blood·Auayporn NademaneeAndrew Raubitschek
Jan 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonUNKNOWN International Harmonization Project on Lymphoma
Nov 26, 2008·Blood·David DaydéGuillaume Cartron
Nov 29, 2008·The New England Journal of Medicine·G LenzUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jane N WinterLeo I Gordon
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William W L ChoiWing C Chan
Apr 16, 2010·The New England Journal of Medicine·Georg Lenz, Louis M Staudt
Jul 28, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian GisselbrechtNorbert Schmitz
Sep 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catherine ThieblemontChristian Gisselbrecht
Oct 19, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nicolas MounierUNKNOWN Lymphoma Working Party of European Blood and Marrow Transplantation Registry (EBMT)
Jan 19, 2012·Cancer·Avichai ShimoniArnon Nagler
Mar 23, 2012·Leukemia·C ViscoK H Young
Mar 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie M VoseMarcie Tomblyn
Jun 19, 2013·Cancer·Zaher I ChakhachiroIssa F Khouri
Oct 29, 2013·Haematologica·Javier BrionesUNKNOWN GELTAMO
Aug 1, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Matthew MeiAmrita Y Krishnan
Mar 17, 2016·Blood·Steven H SwerdlowElaine S Jaffe
Apr 28, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ginna G LaportUNKNOWN Blood and Marrow Transplant Clinical Trials Network
Dec 17, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Issa F KhouriPadmanee Sharma