Updates in Laboratory Diagnostics for Invasive Fungal Infections.

Journal of Clinical Microbiology
David Terrero-Salcedo, Margaret V Powers-Fletcher

Abstract

Appropriate diagnosis of invasive fungal infections (IFIs) is critical due to the high rates of morbidity and mortality, as well as the substantial economic burden, associated with the management of these diseases. The recognition of IFI and differentiation from other infections with similar clinical presentations can be challenging, which can lead to diagnostic error that not only has an impact on individual patient health outcomes but also on antimicrobial drug usage and the growing threat of antimicrobial resistance in bacteria. Therefore, there is a significant need for improved stewardship related to diagnostic testing for and treatment of IFIs. The purpose of this review is to highlight recent advances related to current fungal diagnostics, as well as explore some of the most innovative technology that has emerged with the potential to shift the paradigm of clinical mycology. In general, this review will discuss research related to enhanced fungal culture utilization and identification techniques, expanded applications of fungal antigen testing, and recently developed molecular assays and other novel nonculture fungal diagnostic approaches. Specifically, the application of mass spectrometry, novel glycobiomarker detection...Continue Reading

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Citations

May 28, 2021·Journal of Hepatology·Javier FernándezEmmanuel Q Wey
May 22, 2021·Infectious Disease Clinics of North America·Sarah E KiddCatriona L Halliday
Jun 22, 2021·Case Reports in Pediatrics·Guwani LiyanageThushari Dissanayake
Aug 27, 2021·Therapeutic Advances in Infectious Disease·Mandeep Singh RahiIshmael A Jaiyesimi
Aug 19, 2021·Journal of Clinical Microbiology·Joshua A LiebermanBrad T Cookson

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