Updates in the management of sinonasal mucosal melanoma

Current Opinion in Otolaryngology & Head and Neck Surgery
Meghan M CrippenJean Anderson Eloy

Abstract

Sinonasal mucosal melanoma (SNMM) is an aggressive cancer with a poor prognosis. Although there is significant study surrounding the treatment of sinonasal malignancies and cutaneous melanomas, the rarity of this tumor has largely precluded robust outcomes analyses. The authors of this review seek to provide an overview of the recent literature related to the treatment of SNMM with added context from our institutional experience with this disease. In the surgical management of sinonasal malignancies and SNMM specifically, resection via endoscopic endonasal technique appears to offer comparable oncologic outcomes versus an open approach. The role of adjuvant therapy continues to be debated, but there is strong evidence for improved rates of local control with radiotherapy after complete resection. In the last few years, significant developments have been made in the study of systemic therapies for cutaneous melanoma. The identification of genetic mutations common to mucosal melanoma has allowed for early trials of targeted therapies, but study is ongoing. Although the study of SNMM is largely limited to small retrospective case series, treatment continues to evolve. Until effective systemic therapies can be identified, endoscopi...Continue Reading

References

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P B ChapmanJ M Kirkwood
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Dec 22, 2010·Archives of Otolaryngology--head & Neck Surgery·Adil BenlyazidThomas Filleron
Mar 7, 2012·Journal of the National Comprehensive Cancer Network : JNCCN·David G PfisterUNKNOWN National Comprehensive Cancer Network
Apr 9, 2013·American Journal of Clinical Oncology·Kaitlin ChristophersonWilliam M Mendenhall
Jun 19, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F Stephen HodiDavid E Fisher
Jun 2, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G J Ledderose, A Leunig
Jun 8, 2014·European Annals of Otorhinolaryngology, Head and Neck Diseases·L GilainN Saroul
Sep 23, 2014·Head & Neck·Fernando LópezAlfio Ferlito
Jun 20, 2015·Cell·UNKNOWN Cancer Genome Atlas Network
Aug 12, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Faruk Kadri BakkalUtku Aydil
Dec 15, 2015·International Journal of Oral and Maxillofacial Surgery·A L N FranciscoM K Ikeda
Dec 18, 2015·Head & Neck·Davide LombardiPiero Nicolai
Apr 12, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Omar BreikDavid Wiesenfeld
May 12, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Rounak B RawalAdam M Zanation
Sep 16, 2016·International Forum of Allergy & Rhinology·Neeraja KonuthulaAlfred M Iloreta
Oct 16, 2016·Radiation Oncology·Gaber PlavcPrimož Strojan
Nov 20, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ben GreenPeter A Brennan
Jan 6, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra P D'AngeloJedd D Wolchok
Feb 7, 2017·Otolaryngologic Clinics of North America·Ghassan Alokby, Roy R Casiano
Mar 21, 2017·Otolaryngologic Clinics of North America·Lawrence KashatAlexander G Chiu
Mar 23, 2017·Critical Reviews in Oncology/hematology·Paolo Antonio AsciertoVito Vanella
Mar 24, 2017·International Journal of Radiation Oncology, Biology, Physics·Masashi KotoUNKNOWN Japan Carbon-Ion Radiation Oncology Study Group
May 12, 2017·American Journal of Rhinology & Allergy·Amar MiglaniDevyani Lal
May 12, 2017·British Journal of Cancer·Moran AmitEhab Y Hanna

❮ Previous
Next ❯

Citations

Apr 26, 2019·The Laryngoscope·Ashwin GantiBobby A Tajudeen
Mar 28, 2020·OncoTargets and Therapy·Shorook Na'araZiv Gil
Nov 23, 2019·Acta Oto-laryngologica·Yuting LaiDehui Wang
Apr 18, 2021·The Laryngoscope·Samer T ElsamnaJean Anderson Eloy
Jul 27, 2021·Journal of Neurological Surgery. Part B, Skull Base·Tiffany N ChaoBert W O'Malley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

ANZ Journal of Surgery
Jarad M MartinLester J Peters
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Ioannis ChatzistefanouKonstantinos Antoniades
Critical Reviews in Oncology/hematology
Paolo Antonio AsciertoVito Vanella
The Cancer Journal
Sarah B GoldbergVeronica Chiang
International Journal of Radiation Oncology, Biology, Physics
Stanislav LazarevRichard Bakst
© 2022 Meta ULC. All rights reserved