Updates on Genome-Wide Association Findings in Eating Disorders and Future Application to Precision Medicine

Current Neuropharmacology
Lauren BreithauptCynthia M Bulik

Abstract

Heterogeneity, frequent diagnostic fluctuation across presentations, and global concerns with the absence of effective treatments all encourage science that moves the field toward individualized or precision medicine in eating disorders. We review recent advances in psychiatric genetics focusing on genome-wide association studies (GWAS) in eating disorders. Given that the only eating disorder to be the subject of GWAS to date is anorexia nervosa, we review anorexia GWAS and enumerate the prospects and challenges of a genomics-driven approach towards personalized intervention in eating disorders.

Citations

Sep 9, 2018·The International Journal of Eating Disorders·Christopher HübelCynthia M Bulik
Aug 1, 2020·The International Journal of Eating Disorders·Mattias StrandAndreas Birgegård
Jun 30, 2019·Frontiers in Neuroscience·P SöderstenC Bergh
Jun 11, 2020·Chronic Stress·Frank R WendtRenato Polimanti
Jul 31, 2021·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Raphael HirtzAnke Hinney
Jan 7, 2022·Transcultural Psychiatry·Jennifer Radden

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Methods Mentioned

BETA
exome sequencing

Software Mentioned

MAGMA
PLINK
ALIGATOR
INRICH
PRSice
GCTA

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

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