Updates on GMSCs Treatment for Autoimmune Diseases

Current Stem Cell Research & Therapy
Feng HuangSong Guo Zheng

Abstract

Autoimmune disease is a refractory disease. Accumulating Evidence has revealed that the manipulation of mesenchymal stem cells may have the potential to control or even treat autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a new line of mesenchymal stem cells that have displayed some potential advantages in controlling and treating autoimmune diseases. In this review, we briefly update the current understanding on the biology of GMSCs and their effects on preventing and treating autoimmune diseases. The availability of gingival mesenchymal stem cells (GMSCs), together with their potent capacity of multi-directional differentiation and inflammatory modulation, making GMSCs an ideal subtype of MSCs in treating autoimmune disease. Our and other studies have launched the earliest appraisal on GMSCs and carried out a lot of biological researches. The clinical trial of GMSCs on patients with autoimmune diseases will further approve their therapeutic effects, as well as its cellular and molecular mechanisms.

Citations

Jun 5, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Lei QiLei Zhang
Mar 19, 2020·Stem Cells International·Li-Li ZhouK M Fawzy El-Sayed
Apr 19, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Wenbin WuSong Guo Zheng
Jul 25, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Wenbin WuSong Guo Zheng

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