Updates on Old and Weary Haematopoiesis

International Journal of Molecular Sciences
Joanna Konieczny, Lorena Arranz

Abstract

Blood formation, or haematopoiesis, originates from haematopoietic stem cells (HSCs), whose functions and maintenance are regulated in both cell- and cell non-autonomous ways. The surroundings of HSCs in the bone marrow create a specific niche or microenvironment where HSCs nest that allows them to retain their unique characteristics and respond rapidly to external stimuli. Ageing is accompanied by reduced regenerative capacity of the organism affecting all systems, due to the progressive decline of stem cell functions. This includes blood and HSCs, which contributes to age-related haematological disorders, anaemia, and immunosenescence, among others. Furthermore, chronological ageing is characterised by myeloid and platelet HSC skewing, inflammageing, and expanded clonal haematopoiesis, which may be the result of the accumulation of preleukaemic lesions in HSCs. Intriguingly, haematological malignancies such as acute myeloid leukaemia have a high incidence among elderly patients, yet not all individuals with clonal haematopoiesis develop leukaemias. Here, we discuss recent work on these aspects, their potential underlying molecular mechanisms, and the first cues linking age-related changes in the HSC niche to poor HSC maintena...Continue Reading

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Citations

Nov 7, 2019·Annual Review of Pathology·Megan A EvansKenneth Walsh
Nov 30, 2019·International Journal of Molecular Sciences·Mónica De la Fuente
Feb 23, 2020·Frontiers in Immunology·Christian GuderFrank A Schildberg
Jul 1, 2020·Stem Cell Reviews and Reports·Ranita GangulyDeepa Bhartiya
May 22, 2019·Journal of Clinical Medicine·Vincent Cuminetti, Lorena Arranz
Nov 25, 2020·Journal of Hematology & Oncology·Lei ZhangJiwang Zhang
Feb 8, 2021·Cellular Immunology·Graham PawelecSuzanne Ostrand-Rosenberg
May 12, 2021·Stem Cell Reviews and Reports·Andrea M PattersonChristie M Orschell
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Eirini Sofia Fasouli, Eleni Katsantoni

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Methods Mentioned

BETA
ELISA

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