Updates on osteonecrosis of the jaw.

Current Opinion in Supportive and Palliative Care
Junro YamashitaCatherine Van Poznak

Abstract

Osteonecrosis of the jaw (ONJ) is an uncommon condition noted to occur in patients with cancer who are receiving intravenous bisphosphonates. The cause of ONJ remains unknown. The leading hypotheses addressing the mechanism of ONJ are reviewed here. The present clinical data suggest that ONJ may occur in approximately 5% of patients with metastatic bone disease. The ability to predict an individual's risk of developing ONJ remains elusive. It is likely that an altered bone microenvironment and/or host defense mechanisms effected by medications used to treat patients with metastatic bone disease contributes to the development of ONJ. Medications that significantly reduce osteoclastic activity are associated with ONJ. Preclinical models of ONJ are being developed but to establish such an intricate systemic condition in animals is challenging. The ONJ field has progressed via knowledge gained by case reports, population-based studies, and emerging animal models. Still, there are myths that need to be resolved and important clues that need to be investigated. Understanding the pathophysiology of this condition will be critical to improve patient care. Communications between oncologists, dentists, basic scientists, and patients are ...Continue Reading

References

Sep 6, 2003·Journal of Clinical Periodontology·G CardaropoliJ Lindhe
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Aug 1, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundeep KhoslaUNKNOWN American Society for Bone and Mineral Research
Aug 10, 2007·British Journal of Haematology·Guy PrattPaul Moss
Dec 19, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Sarandeep S Huja, Frank M Beck
Apr 22, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Matthew R Allen, David B Burr
May 20, 2008·British Journal of Haematology·Ashraf BadrosElizabeth Streeten
Jul 11, 2008·The Oncologist·Andrea Wang-GillamLaura F Hutchins
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cherry L EstiloJoseph M Huryn
Nov 4, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GreuterB Thuerlimann
Dec 4, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Luis CardosoMitchell B Schaffler
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chiara AgratiFederico Martini
Feb 4, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J AyllonS Oudard
Apr 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katherine D CrewDawn L Hershman
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Matthew R Allen, David B Burr
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Richard Gliklich, Jerome Wilson
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·John J Freiberger
May 9, 2009·Nature Reviews. Clinical Oncology·Victoria L Heath, Roy Bicknell
May 12, 2009·BJU International·Donald L TrumpCandace S Johnson
May 14, 2009·Journal of Bone and Mineral Metabolism·Hisato HikitaShigemi Goto
Jun 6, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Neil Binkley
Jun 27, 2009·Immunopharmacology and Immunotoxicology·Yu-Jen ChenYu-Yawn Chen
Jul 3, 2009·The Journal of the American Dental Association·Soulafa A Almazrooa, Sook-Bin Woo
Jul 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Matthew R AllenDavid B Burr
Oct 3, 2009·The Journal of the American Dental Association·Parish P SedghizadehJ William Costerton
Oct 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Konstantinos VahtsevanosKonstantinos Antoniades
Nov 6, 2009·Blood·Frank C CackowskiG David Roodman
Feb 6, 2010·The Journal of Clinical Endocrinology and Metabolism·John S Adams, Martin Hewison
Feb 11, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sven OttoGerson Mast
Feb 11, 2010·Current Opinion in Immunology·Alberto Mantovani, Antonio Sica
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Akishige HokugoIchiro Nishimura
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takashi KikuiriSongtao Shi
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kenneth M KozloffMichelle S Caird

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Citations

May 11, 2011·Journal of Dental Research·J D BashutskiL K McCauley
Oct 17, 2012·Journal of Dental Research·H L Chan, L K McCauley
Oct 17, 2012·The Journal of Evidence-based Dental Practice·Junro Yamashita, Laurie K McCauley
Jul 16, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Renato Nicolás HoppJacks Jorge
Jul 29, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Aydin KeskinruzgarSedat Cetiner
Nov 22, 2013·Journal of Periodontal Research·S H SteinD A Tipton
Aug 10, 2018·The Journal of International Medical Research·Henrik HoltmannRita Depprich
Mar 31, 2017·Molecular and Clinical Oncology·Daigo YamamotoMasanori Kon
Aug 20, 2015·Food Science & Nutrition·Oluwaseun P BamideleBeatrice M Fasogbon
Nov 28, 2016·Microvascular Research·Andrea SzabóMihály Boros
Jul 2, 2021·The Analyst·Susanne ReierAndreas Walter

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