Updates on Sjögren's syndrome: from proteomics to protein biomarkers

Expert Review of Proteomics
C BaldiniS Bombardieri

Abstract

Primary Sjögren's syndrome (pSS) is a complex heterogeneous autoimmune disorder, typically affecting exocrine glands. Recently, a great interest has arisen in searching for novel biomarkers able to improve the diagnostic work-up of the disease as well as the general assessment and the prognostic stratification of pSS patients. From this perspective, salivary proteomics has appeared as a promising tool considering that salivary proteins may closely reflect the underlying disease processes in the salivary glands. Areas covered: Here we will provide an update on the state of the art of proteomics in pSS, focusing in particular on putative novel biomarkers for the disease. There is a special focus on candidate salivary protein and their role in non-invasive diagnosis of pSS. Expert commentary: Proteomics represents an emerging throughput omics-based approach for use in diagnosis of pSS. The studies that have been presented in this review have provided major contributions towards the identification of putative protein biomarkers, that once validated, could be able not only to contribute to a non-invasive diagnosis of pSS but also to the stratification of different disease subsets, ultimately allowing a better comprehension of the di...Continue Reading

References

Sep 20, 1993·Annals of the New York Academy of Sciences·A VissinkC G Kallenberg
Mar 1, 1996·The Journal of Experimental Medicine·G RaposoH J Geuze
May 1, 1996·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·A VissinkA Van Nieuw Amerongen
Oct 16, 2004·Archives of Oral Biology·Chun-Ming Huang
May 10, 2005·Arthritis and Rheumatism·Efstathia K KapsogeorgouMenelaos N Manoussakis
Oct 31, 2007·Arthritis and Rheumatism·Shen HuDavid T Wong
Dec 11, 2007·Expert Review of Proteomics·Laura GiustiAntonio Lucacchini
Jan 15, 2008·Autoimmunity Reviews·Chiara BaldiniStefano Bombardieri
Jan 30, 2008·Current Protocols in Cell Biology·Clotilde ThéryAled Clayton
Jun 23, 2009·Critical Reviews in Immunology·Alexander D McLellan
Jul 10, 2010·Arthritis Care & Research·Shen HuDavid T Wong
Dec 8, 2010·Proteomics. Clinical Applications·Laura GiustiStefano Bombardieri
Jan 8, 2011·Biological & Pharmaceutical Bulletin·Yuko OgawaRyohei Yanoshita
Dec 1, 2010·Therapeutic Advances in Musculoskeletal Disease·Michael Voulgarelis, Athanasios G Tzioufas
Aug 14, 2012·Proteomics·Kiran S AmbatipudiJames E Melvin
May 31, 2013·Methods in Molecular Biology·Alessia Gallo, Ilias Alevizos
Jul 25, 2013·Experimental Eye Research·Nadine von Thun Und Hohenstein-BlaulFranz H Grus
Feb 11, 2015·Nature Reviews. Rheumatology·Athanasios G Tzioufas, Efstathia K Kapsogeorgou
Jul 8, 2016·Nature Reviews. Disease Primers·Pilar Brito-ZerónManuel Ramos-Casals
Jul 23, 2016·Immunologic Research·Andreas V Goules, Athanasios G Tzioufas

❮ Previous
Next ❯

Citations

Feb 21, 2018·Biomarkers in Medicine·Chiara BaldiniStefano Bombardieri
Mar 14, 2019·Frontiers in Immunology·Iris L A BodewesMarjan A Versnel
Jun 20, 2019·Analytical and Bioanalytical Chemistry·Andrei StefancuDaniela Fodor
Jun 3, 2021·International Journal of Molecular Sciences·Francesco FinamoreChiara Baldini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.