Updates on the Mechanisms and the Care of Cardiovascular Calcification in Chronic Kidney Disease

Seminars in Nephrology
Lucie HénautZiad Massy

Abstract

In chronic kidney disease (CKD), the progressive decrease in renal function leads to disturbances of mineral metabolism that generally cause secondary hyperparathyroidism. The increase in serum parathyroid hormone is associated with reduced serum calcium and calcitriol levels and/or increased serum fibroblast growth factor-23 and phosphate levels. The resulting CKD-associated disorder of mineral and bone metabolism is associated with various other metabolic dysregulations such as acidosis, malnutrition, inflammation, and accumulation of uremic toxins. It favors the occurrence of vascular calcification, which results from an imbalance between numerous inhibitors and promoters of soft-tissue mineralization. This review provides an overview of the most recent state of knowledge concerning the mechanisms that lead to the development of vascular calcification in the CKD setting. It further proposes directions for potential new therapeutic targets.

Citations

May 10, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tilman B Drüeke, Ziad A Massy
Apr 16, 2019·Current Opinion in Nephrology and Hypertension·Jakob VoelklIoana Alesutan
Apr 9, 2020·Toxins·Guillaume LanoMarion Sallée
Jul 25, 2018·Toxins·Maryam AssemLucie Hénaut
Mar 20, 2019·Cellular and Molecular Life Sciences : CMLS·Jakob VoelklIoana Alesutan
Jul 10, 2020·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Diego Ennes GonzalezAluizio Barbosa Carvalho
Jul 25, 2019·Journal of Clinical Medicine·Antonio BellasiBiagio Raffaele Di Iorio
Jun 5, 2020·Vascular Health and Risk Management·Sepideh Zununi VahedMohammadreza Ardalan
Feb 28, 2020·Nutrients·Atsushi ShioiMasanori Emoto
Jan 7, 2021·Toxins·Nikolaos C KyriakidisPeter Stenvinkel
May 1, 2021·Biomedicines·Prabhatchandra DubeDavid Kennedy
May 6, 2021·European Journal of Clinical Investigation·Fernanda G RodriguesMartin H de Borst

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