[Updating in prescription of proton pump inhibitors. What to do and what not to do].

Semergen
G M Saiz LaderaJ N García Pascual

Abstract

Proton pump inhibitors (PPIs) are the most prescribed pharmacological subgroup of the National Health System and their use has been related to possible potentially serious adverse effects. To review the current indications for treatment with PPIs as well as the data related to their safety, in order to promote their adecuate use. A review of the literature focused on the following topics has been carried out: a) molecules and mechanism of action; b) current indications for treatment and adherence to them; c) adverse effects related to its use; d) drug interactions; e) alternatives in deprescription. The current indications have not changed substantially in recent years and are well established, however, there is a high percentage of inappropriate prescription, mainly in individuals with low or no risk. PPIs are safe drugs and generally well tolerated and their benefits are higher than possible adverse effects. Adhering to evidence-based recommendations represents the only rational approach to safe and effective therapy.

References

Jan 31, 2006·The American Journal of Medicine·Victor L Serebruany
Feb 26, 2009·The American Journal of Gastroenterology·Frank L LanzaUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Jun 2, 2009·Gastroenterology·Kenneth E L McColl, Derek Gillen
Jun 28, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Angel LanasEdward J Mills
Feb 20, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ralph-Steven Wedemeyer, Henning Blume
Jul 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hai-Yin JiangBing Ruan
Jun 24, 2015·International Journal of Clinical Pharmacy·Helen F Boardman, Gordon Heeley
Mar 10, 2016·Alimentary Pharmacology & Therapeutics·B P M VerhaeghD M A E Jonkers
Apr 2, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Cristóbal de la Coba OrtizFroilán Giganto Tomé
May 24, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·An Tran-DuyCoen D A Stehouwer
Jul 17, 2016·Journal of Clinical Pharmacy and Therapeutics·S AndradeJ Gurwitz
Oct 14, 2016·The Annals of Pharmacotherapy·Ernest H LawTodd A Lee
Nov 9, 2016·BMC Medicine·Carmelo ScarpignatoUNKNOWN Italian Society of Pharmacology, the Italian Association of Hospital Gastroenterologists, and the Italian Federation of Gene
Jan 17, 2017·Journal of Gastroenterology and Hepatology·Leonardo Henry EusebiFranco Bazzoli
Jan 28, 2017·Journal of Gastroenterology and Hepatology·Riley BatchelorDanny Liew
Feb 6, 2017·Clinical Therapeutics·Marko SkelinDario Rahelić
Mar 23, 2017·International Heart Journal·Wengen Zhu, Kui Hong
Aug 29, 2017·KI Reports·Stephanie Toth-Manikowski, Morgan E Grams
Oct 2, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David Y Graham, Aylin Tansel
Dec 5, 2017·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Altay Çelebi, Hasan Yılmaz
Feb 7, 2018·Mayo Clinic Proceedings·Avinash K NehraVandana Nehra
Apr 3, 2018·Journal of Neurogastroenterology and Motility·Yoshikazu KinoshitaShunji Ishihara
Apr 17, 2018·Basic & Clinical Pharmacology & Toxicology·Peter Fentz HaastrupDorte Ejg Jarbøl
May 15, 2018·Neural Plasticity·Gloria Ortiz-GuerreroMauricio Orlando Nava Mesa
Jul 17, 2018·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Carine Franco MorschelJosé Carlos Carraro Eduardo
Aug 11, 2018·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Vincenzo SavarinoGerardo Nardone
Sep 22, 2018·Journal of Bone Metabolism·Yousef Nassar, Seth Richter
Sep 10, 2019·Expert Opinion on Drug Safety·Aitor Lanas-GimenoÁngel Lanas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Singapore Medical Journal
Christopher Tze Wei ChiaCharles Kien Fong Vu
American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Roman A Sukhovershin, John P Cooke
© 2021 Meta ULC. All rights reserved