Updating long-term childhood cancer survival trend with period and mixed analysis: good news from population-based estimates in Italy

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Luisa ZuccoloCorrado Magnani

Abstract

An empirical evaluation of long-term period survival analysis was performed using data from the Childhood Cancer Registry of Piedmont, Italy. The aim was to update survival time trends and provide 25-year projections for children currently diagnosed with cancer. The observed survival experiences up to 15 years after diagnosis of five quinquennial cohorts (cohort analysis) were compared to the corresponding estimates obtained by period analysis. The two methods generally produced very similar findings, although period analysis estimates were slightly lower than those obtained from cohort analysis. We then used mixed analysis to assess time trends in long-term survival. This showed that the probability of surviving 25 years after a cancer in childhood has more than doubled compared to cohort analysis estimates from patients diagnosed more than 25 years ago (73% vs. 32%), providing further evidence of an ongoing improvement in prognosis.

References

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Citations

Sep 11, 2008·Journal of the National Cancer Institute·Dianne PulteHermann Brenner
Nov 18, 2008·Revue D'épidémiologie Et De Santé Publique·B Trombert-PaviotF Freycon
Sep 18, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Daniela AlessiFranco Merletti
Mar 3, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hermann Brenner, Timo Hakulinen
Jan 25, 2019·Pediatric Blood & Cancer·Elena IsaevskaMilena Maule
Aug 9, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Hermann Brenner, Timo Hakulinen

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