Updating meta-analyses leads to larger type I errors than publication bias

Journal of Clinical Epidemiology
George F Borm, A Rogier T Donders

Abstract

To estimate the extent to which the practice of periodically updating meta-analyses causes inflation of the type I error and then to compare the estimate with the inflation caused by publication bias. We also present a simple method to adjust for the inflation associated with updating meta-analyses. Simulations were used to estimate the error rates. In general, updating meta-analyses caused 2- to 5-fold inflation of the type I error rates, which exceeded the inflation caused by publication bias. As a rule of thumb, the results of a meta-analysis are robust up to 5, 10, 15, or 22 updates, if the P-value multiplied by 4, 6, 8, or 10 remains below the desired significance level. Meta-analyses are likely to be updated until a clear conclusion is reached. Therefore, it is important to take the inflation of the error rate into account to interpret the results correctly.

References

Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 31, 2005·The New England Journal of Medicine·Deborah A ZarinNicholas C Ide
Oct 10, 2006·Epidemiology·Casper W BollenIngeborg van der Tweel
Sep 13, 2007·Clinical Trials : Journal of the Society for Clinical Trials·Mingxiu HuK K Gordon Lan

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Citations

Nov 28, 2012·PloS One·Porjai PattanittumChetta Ngamjarus
Sep 10, 2010·Kidney International·Sumit Mohan, Jai Radhakrishnan
Nov 6, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Poramate Pitak-ArnnopNiels Christian Pausch
May 19, 2009·The Breast : Official Journal of the European Society of Mastology·Huihua LiBee Choo Tai
Jun 9, 2015·Research Synthesis Methods·Elena Kulinskaya, John Wood
Oct 7, 2015·International Journal of Cardiology·Kevin PhanTristan D Yan
Apr 4, 2015·Journal of Alzheimer's Disease : JAD·Jia-Hao SunJin-Tai Yu
Aug 25, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M J Bown, A J Sutton
Jan 29, 2016·Clinical Pharmacology and Therapeutics·Sheila A FisherEnca Martin-Rendon
Nov 3, 2016·Anaesthesia·A AfshariA F Smith
Oct 17, 2012·Statistical Methods in Medical Research·Joanna IntHoutGeorge F Borm
Sep 18, 2013·Journal of Psychopharmacology·Konstantinos N FountoulakisMelina Siamouli
Dec 25, 2016·The Cochrane Database of Systematic Reviews·Sheila A FisherEnca Martin-Rendon
Oct 5, 2018·Diseases of the Colon and Rectum·Karim Alavi
Jun 9, 2016·European Journal of Anaesthesiology·Edoardo De RobertisDan Longrois
Jul 17, 2020·Critical Care Explorations·Diego Escarramán-MartínezEder Iván Zamarrón López
Nov 20, 2016·Transfusion·Chatree Chai-AdisaksophaAlfonso Iorio
Dec 24, 2014·European Journal of Anaesthesiology·Arash Afshari, Jørn Wetterslev
Oct 1, 2015·The Cochrane Database of Systematic Reviews·Sheila A FisherEnca Martin-Rendon
May 21, 2019·Anaesthesia·A Shah, A F Smith
May 15, 2019·ANZ Journal of Surgery·Wen-Shan YanPeng Zhang
Jan 25, 2021·Frontiers in Zoology·Leila Siciliano-MartinaA Michelle Lawing
Aug 19, 2020·The Journal of Thoracic and Cardiovascular Surgery·Stephanie K TomKendra J Grubb
May 5, 2021·Anesthesia and Pain Medicine·Hyun Kang
Sep 2, 2020·The Journal of Thoracic and Cardiovascular Surgery·Jeffrey Shi Kai Chan, Amer Harky

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